Literature summary for 3.4.15.1 extracted from

Hagiwara, S.Y.; Takahashi, M.; Shen, Y.; Kaihou, S.; Tomiyama, T.; Yazawa, M.; Tamai, Y.; Sin, Y.; Kazusaka, A.; Terazawa, M.
A phytochemical in the edible Tamogi-take mushroom (Pleurotus cornucopiae), D-mannitol, inhibits ACE activity and lowers the blood pressure of spontaneously hypertensive rats (2005), Biosci. Biotechnol. Biochem., 69, 1603-1605.

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Inhibitors

Inhibitors	Comment	Organism	Structure
D-mannitol	IC50: 3 mg/ml	Bos taurus
D-mannitol	antihypertensive effect in spontaneously hypertensive rats by oral administration	Rattus norvegicus
additional information	hot water extract of Tamogi-take mushroom, IC50: 6 mg/ml	Bos taurus
additional information	hot water extract of Tamogi-take mushroom, antihypertensive effect in spontaneously hypertensive rats by oral administration	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	-	Rattus norvegicus	-
lung	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
hippuryl-His-Leu + H2O	-	Bos taurus	hippuric acid + His-Leu	-	?

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Release 2023.1 (January 2023)