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Literature summary for 3.4.15.1 extracted from
- ACE2 overexpression inhibits angiotensin II-induced monocyte chemoattractant protein-1 expression in macrophages (2008), Arch. Med. Res., 39, 149-154.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | ACE2 overexpression may provide a therapeutic strategy for atherosclerosis by inhibiting production of monocyte chemoattractant protein-1 (MCP-1) induced by angiotensin II. ACE2 produces beneficial effects on prevention of atherosclerosis | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| a truncated form of mouse ACE2 is cloned into adenovirus vector (Ad-ACE2) and transfected into human THP-1 macrophages | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ramipril | - |
Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 7-amido-4-carboxymethylcoumarin-YVADAPK(Dnp)-OH + H2O | - |
Mus musculus | dinitrophenol + 7-amino-4-carbamoylmethylcoumarin-YVADAPK | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACE2 | - |
Mus musculus |
| mACE2 | - |
Mus musculus |
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Release 2023.1 (January 2023)
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