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Literature summary for 3.4.15.1 extracted from

  • Papakyriakou, A.; Spyroulias, G.A.; Sturrock, E.D.; Manessi-Zoupa, E.; Cordopatis, P.
    Simulated interactions between angiotensin-converting enzyme and substrate gonadotropin-releasing hormone: novel insights into domain selectivity (2007), Biochemistry, 46, 8753-8765.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens P12821
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
gonadotropin-releasing hormone + H2O a bridging interaction between Arg500 of the N-domain and Arg8 of gonadotropin-releasing hormone that involves a buried chloride ion may account for its role in the specificity of the N-domain for endoproteolytic cleavage of the substrate at the NH2-terminus in vitro Homo sapiens ?
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Synonyms

Synonyms Comment Organism
ACE
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Homo sapiens
angiotensin-I converting enzyme
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Homo sapiens