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Literature summary for 3.4.15.1 extracted from

  • An, J.J.; Zhou, J.L.; Li, H.J.; Jiang, Y.; Li, P.
    Puqienine E: an angiotensin converting enzyme inhibitory steroidal alkaloid from Fritillaria puqiensis (2010), Fitoterapia, 81, 149-152.
    View publication on PubMed
Search for more literature for 3.4.15.1

Inhibitors

Inhibitors Comment Organism Structure
captopril 98.5% inhibition at 0.2 mM Oryctolagus cuniculus
peimisine an ACE inhibitory steroidal alkaloid from Fritillaria puqiensis, 20.2% inhibition at 0.2 mM Oryctolagus cuniculus
puqiedine an ACE inhibitory steroidal alkaloid from Fritillaria puqiensis, 6.1% inhibition at 0.2 mM Oryctolagus cuniculus
puqienine A an ACE inhibitory steroidal alkaloid from Fritillaria puqiensis, 20.4% inhibition at 0.2 mM Oryctolagus cuniculus
puqienine B an ACE inhibitory steroidal alkaloid from Fritillaria puqiensis, 24.7% inhibition at 0.2 mM Oryctolagus cuniculus
puqienine C an ACE inhibitory steroidal alkaloid from Fritillaria puqiensis, 19.8% inhibition at 0.2 mM Oryctolagus cuniculus
puqienine D an ACE inhibitory steroidal alkaloid from Fritillaria puqiensis, 16.5% inhibition at 0.2 mM Oryctolagus cuniculus
puqienine E an ACE inhibitory steroidal alkaloid from Fritillaria puqiensis, 72% inhibition at 0.2 mM Oryctolagus cuniculus
puqietinone an ACE inhibitory steroidal alkaloid from Fritillaria puqiensis, 9.3% inhibition at 0.2 mM Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Oryctolagus cuniculus
-
 angiotensin II + His-Leu
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation type VI-S Oryctolagus cuniculus
-
lung
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
 Oryctolagus cuniculus angiotensin II + His-Leu
-
 ?
hippuryl-His-Leu + H2O
-
 Oryctolagus cuniculus hippuric acid + His-Leu
-
 ?

Synonyms

Synonyms Comment Organism
ACE
-
 Oryctolagus cuniculus
angiotensin converting enzyme
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Oryctolagus cuniculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000014
-
 37°C Oryctolagus cuniculus captopril
0.068
-
 37°C Oryctolagus cuniculus puqienine E
0.6
-
 37°C Oryctolagus cuniculus puqienine B
1
-
 37°C Oryctolagus cuniculus puqienine A