Cloned (Comment) | Organism |
---|---|
expression of soluble wild-type and mutant enzymes in CHO and HEK-293 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
L19E | the mutation alters the binding of monoclonal antibodies to the N domain of ACE and shedding of ACE domains | Homo sapiens |
Q18H | the mutation alters the binding of monoclonal antibodies to the N domain of ACE and shedding of ACE domains | Homo sapiens |
Q22A | the mutation alters the binding of monoclonal antibodies to the N domain of ACE and shedding of ACE domains | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | - |
Homo sapiens | |
lisinopril | - |
Homo sapiens | |
additional information | monoclonal antibosies mAbs 9B9 and 3G8 prevent ACE dimerization in vitro in reverse micelles, and only mAb 3G8 inhibits ACE shedding from the cell surface | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
membrane | cell surface | Homo sapiens | 16020 | - |
additional information | ACE undergoes domain shedding and changes from membrane to soluble status | Homo sapiens | - |
- |
soluble | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | ACE is a zinc-metalloprotease | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P12821 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ascites fluid | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
plasma | - |
Homo sapiens | - |
semen | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hippuryl-His-Leu + H2O | - |
Homo sapiens | hippuric acid + His-Leu | - |
? | |
Z-phenylalanyl-histidyl-leucine + H2O | - |
Homo sapiens | Z-phenylalanine + histidyl-leucine | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | the N domain of ACE influences domain shedding and enzyme dimerization, overview. Epitope mapping using monoclonal antibodies directed to the N domain of ACE, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ACE | - |
Homo sapiens |
angiotensin-I-converting enzyme | - |
Homo sapiens |
CD143 | - |
Homo sapiens |
peptidyl dipeptidase | - |
Homo sapiens |
sACE | - |
Homo sapiens |
somatic ACE | - |
Homo sapiens |