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Literature summary for 3.4.15.1 extracted from

  • Gordon, K.; Balyasnikova, I.V.; Nesterovitch, A.B.; Schwartz, D.E.; Sturrock, E.D.; Danilov, S.M.
    Fine epitope mapping of monoclonal antibodies 9B9 and 3G8 to the N domain of angiotensin-converting enzyme (CD143) defines a region involved in regulating angiotensin-converting enzyme dimerization and shedding (2010), Tissue Antigens, 75, 136-150.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of soluble wild-type and mutant enzymes in CHO and HEK-293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
L19E the mutation alters the binding of monoclonal antibodies to the N domain of ACE and shedding of ACE domains Homo sapiens
Q18H the mutation alters the binding of monoclonal antibodies to the N domain of ACE and shedding of ACE domains Homo sapiens
Q22A the mutation alters the binding of monoclonal antibodies to the N domain of ACE and shedding of ACE domains Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
EDTA
-
Homo sapiens
lisinopril
-
Homo sapiens
additional information monoclonal antibosies mAbs 9B9 and 3G8 prevent ACE dimerization in vitro in reverse micelles, and only mAb 3G8 inhibits ACE shedding from the cell surface Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-
membrane cell surface Homo sapiens 16020
-
additional information ACE undergoes domain shedding and changes from membrane to soluble status Homo sapiens
-
-
soluble
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ ACE is a zinc-metalloprotease Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P12821
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
ascites fluid
-
Homo sapiens
-
kidney
-
Homo sapiens
-
lung
-
Homo sapiens
-
plasma
-
Homo sapiens
-
semen
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hippuryl-His-Leu + H2O
-
Homo sapiens hippuric acid + His-Leu
-
?
Z-phenylalanyl-histidyl-leucine + H2O
-
Homo sapiens Z-phenylalanine + histidyl-leucine
-
?

Subunits

Subunits Comment Organism
dimer the N domain of ACE influences domain shedding and enzyme dimerization, overview. Epitope mapping using monoclonal antibodies directed to the N domain of ACE, overview Homo sapiens

Synonyms

Synonyms Comment Organism
ACE
-
Homo sapiens
angiotensin-I-converting enzyme
-
Homo sapiens
CD143
-
Homo sapiens
peptidyl dipeptidase
-
Homo sapiens
sACE
-
Homo sapiens
somatic ACE
-
Homo sapiens