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Literature summary for 3.4.15.1 extracted from
- Angiotensin-converting enzyme inhibitory effects by plant phenolic compounds: a study of structure activity relationships (2013), J. Agric. Food Chem., 61, 11832-11839.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-coumaric acid | - |
Oryctolagus |  |
| 4-coumaric acid | - |
Oryctolagus cuniculus | |
| 4-hydroxybenzoic acid | - |
Oryctolagus | |
| 4-hydroxybenzoic acid | - |
Oryctolagus cuniculus | |
| apigenin | - |
Oryctolagus | |
| apigenin | - |
Oryctolagus cuniculus | |
| benzoic acid | - |
Oryctolagus | |
| benzoic acid | - |
Oryctolagus cuniculus | |
| caffeic acid | - |
Oryctolagus | |
| caffeic acid | - |
Oryctolagus cuniculus | |
| catechol | - |
Oryctolagus | |
| catechol | - |
Oryctolagus cuniculus | |
| ellagic acid | - |
Oryctolagus | |
| ellagic acid | - |
Oryctolagus cuniculus | |
| epicatechin | - |
Oryctolagus | |
| epicatechin | - |
Oryctolagus cuniculus | |
| ferulic acid | - |
Oryctolagus | |
| ferulic acid | - |
Oryctolagus cuniculus | |
| gallic acid | - |
Oryctolagus | |
| gallic acid | - |
Oryctolagus cuniculus | |
| kaempferol | - |
Oryctolagus | |
| kaempferol | - |
Oryctolagus cuniculus | |
| phloretin | - |
Oryctolagus | |
| phloretin | - |
Oryctolagus cuniculus | |
| protocatechuic acid | - |
Oryctolagus | |
| protocatechuic acid | - |
Oryctolagus cuniculus | |
| pyrogallol | - |
Oryctolagus | |
| pyrogallol | - |
Oryctolagus cuniculus | |
| quercetin | - |
Oryctolagus | |
| quercetin | - |
Oryctolagus cuniculus | |
| resveratrol | - |
Oryctolagus | |
| resveratrol | - |
Oryctolagus cuniculus | |
| rutin | - |
Oryctolagus | |
| rutin | - |
Oryctolagus cuniculus | |
| syringic acid | - |
Oryctolagus | |
| syringic acid | - |
Oryctolagus cuniculus | |
| Tannic acid | - |
Oryctolagus | |
| Tannic acid | - |
Oryctolagus cuniculus | |
| trans-cinnamic acid | - |
Oryctolagus | |
| trans-cinnamic acid | - |
Oryctolagus cuniculus | |
| vanillic acid | - |
Oryctolagus | |
| vanillic acid | - |
Oryctolagus cuniculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung | - |
Oryctolagus cuniculus | - |
| lung | - |
Oryctolagus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| hippuryl-His-Leu + H2O | - |
Oryctolagus | hippuric acid + His-Leu | - |
? | |
| hippuryl-L-His-L-Leu + H2O | - |
Oryctolagus cuniculus | hippuric acid + L-His-L-Leu | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACE | - |
Oryctolagus cuniculus |
| ACE | - |
Oryctolagus |
| angiotensin-converting enzyme | - |
Oryctolagus cuniculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Oryctolagus cuniculus |
| 37 | - |
assay at | Oryctolagus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.23 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | Tannic acid | |
| 0.23 | - |
pH not specified in the publication, 37°C | Oryctolagus | Tannic acid | |
| 0.415 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | quercetin | |
| 0.415 | - |
pH not specified in the publication, 37°C | Oryctolagus | quercetin | |
| 0.472 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | rutin | |
| 0.472 | - |
pH not specified in the publication, 37°C | Oryctolagus | rutin | |
| 0.512 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | kaempferol | |
| 0.512 | - |
pH not specified in the publication, 37°C | Oryctolagus | kaempferol | |
| 0.667 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | apigenin | |
| 0.667 | - |
pH not specified in the publication, 37°C | Oryctolagus | apigenin | |
| 0.97 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | resveratrol | |
| 0.97 | - |
pH not specified in the publication, 37°C | Oryctolagus | resveratrol | |
| 1.1 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | phloretin | |
| 1.1 | - |
pH not specified in the publication, 37°C | Oryctolagus | phloretin | |
| 1.12 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | pyrogallol | |
| 1.12 | - |
pH not specified in the publication, 37°C | Oryctolagus | pyrogallol | |
| 1.381 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | epicatechin | |
| 1.381 | - |
pH not specified in the publication, 37°C | Oryctolagus | epicatechin | |
| 2 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | ellagic acid | |
| 2 | - |
pH not specified in the publication, 37°C | Oryctolagus | ellagic acid | |
| 2.1 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | caffeic acid | |
| 2.1 | - |
pH not specified in the publication, 37°C | Oryctolagus | caffeic acid | |
| 2.8 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | 4-coumaric acid | |
| 2.8 | - |
pH not specified in the publication, 37°C | Oryctolagus | 4-coumaric acid | |
| 3.7 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | gallic acid | |
| 3.7 | - |
pH not specified in the publication, 37°C | Oryctolagus | gallic acid | |
| 4.4 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | ferulic acid | |
| 4.4 | - |
pH not specified in the publication, 37°C | Oryctolagus | ferulic acid | |
| 5.07 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | protocatechuic acid | |
| 5.07 | - |
pH not specified in the publication, 37°C | Oryctolagus | protocatechuic acid | |
| 5.95 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | 4-hydroxybenzoic acid | |
| 5.95 | - |
pH not specified in the publication, 37°C | Oryctolagus | 4-hydroxybenzoic acid | |
| 6.2 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | benzoic acid | |
| 6.2 | - |
pH not specified in the publication, 37°C | Oryctolagus | benzoic acid | |
| 7.7 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | catechol | |
| 7.7 | - |
pH not specified in the publication, 37°C | Oryctolagus | catechol | |
| 8 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | vanillic acid | |
| 8 | - |
pH not specified in the publication, 37°C | Oryctolagus | vanillic acid | |
| 8.5 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | trans-cinnamic acid | |
| 8.5 | - |
pH not specified in the publication, 37°C | Oryctolagus | trans-cinnamic acid | |
| 9.3 | - |
37°C, pH not specified in the publication | Oryctolagus cuniculus | syringic acid | |
| 9.3 | - |
pH not specified in the publication, 37°C | Oryctolagus | syringic acid | |
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