Inhibitors | Comment | Organism | Structure |
---|---|---|---|
SPB1 | Bacillus subtilis crude lipopeptide biosurfactant, the biosurfactant displays a potent inhibition of ACE activity in vitro, IC50 is 1.37 mg/ml | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | Rattus norvegicus | - |
angiotensin II + L-His-L-Leu | - |
? | |
angiotensin I + H2O | Rattus norvegicus Wistar | - |
angiotensin II + L-His-L-Leu | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P47820 | - |
- |
Rattus norvegicus Wistar | P47820 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | - |
Rattus norvegicus | angiotensin II + L-His-L-Leu | - |
? | |
angiotensin I + H2O | - |
Rattus norvegicus Wistar | angiotensin II + L-His-L-Leu | - |
? | |
N-[3-(2-furyl)acryloyl]-L-phenylalanylglycylglycine + H2O | - |
Rattus norvegicus | ? | - |
? | |
N-[3-(2-furyl)acryloyl]-L-phenylalanylglycylglycine + H2O | - |
Rattus norvegicus Wistar | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACE | - |
Rattus norvegicus |
angiotensin I-converting enzyme | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | protective and the curative effects of Bacillus subtilis SPB1 crude lipopeptide biosurfactant in alleviating induced obesity complications in rats fed on high-fat-high-fructose diet (HFFD) via inhibition of ACE activity. Administration of SPB1 biosurfactant reduced significantly (34%) the peak of blood glucose concentration 60 min after glucose administration, as compared with untreated rats fed on HFFD. SPB1 lipopeptides treatments improves some of serum electrolytes such as Na+, K+, Ca2+, and Mg2+ | Rattus norvegicus |