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Literature summary for 3.4.15.1 extracted from

  • Strittmatter, S.M.; Thiele, E.A.; Kapiloff, M.S.; Snyder, S.H.
    A rat brain isozyme of angiotensin-converting enzyme. Unique specificity for amidated peptide substrates (1985), J. Biol. Chem., 260, 9825-9832.
    View publication on PubMed
Search for more literature for 3.4.15.1

Inhibitors

Inhibitors Comment Organism Structure
captopril
-
 Rattus norvegicus
EDTA
-
 Rattus norvegicus
S-acetylcaptopril
-
 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
165000
-
 x * 165000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O Rattus norvegicus i.e. substance P, lung and brain ACE cleave substance P via two pathways. In one pathway ACE first releases Gly-Leu-Met-NH2 and then dipeptides sequentially from the carboxyl terminus. The other first produces Leu-Met-NH2 and then releases dipeptides to leave substance P(1-5) ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain corpus striatum Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O i.e. substance P Rattus norvegicus Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly + Leu-Met-NH2
-
 ?
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O lung and brain ACE cleave substance P via two pathways. In one pathway ACE first releases Gly-Leu-Met-NH2 and then dipeptides sequentially from the carboxyl terminus. The other first produces Leu-Met-NH2 and then releases dipeptides to leave substance P(1-5) Rattus norvegicus Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly + Leu-Met-NH2
-
 ?
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O i.e. substance P, lung and brain ACE cleave substance P via two pathways. In one pathway ACE first releases Gly-Leu-Met-NH2 and then dipeptides sequentially from the carboxyl terminus. The other first produces Leu-Met-NH2 and then releases dipeptides to leave substance P(1-5) Rattus norvegicus ?
-
 ?
hippuryl-His-Leu + H2O
-
 Rattus norvegicus hippuric acid + His-Leu
-
 ?
His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 + H2O i.e. substance K, degraded by striatal but not by lung enzyme Rattus norvegicus His-Lys-Thr-Asp-Ser-Phe-Val-Gly + Leu-Met-NH2
-
 ?
Luteinizing hormone-releasing hormone + H2O degraded by striatal and by lung enzyme Rattus norvegicus ?
-
 ?
N-(1-(S)-carboxy-3-phenylpropyl)-L-Ala-L-Pro + H2O i.e. MK-422 Rattus norvegicus ?
-
 ?
N-(1-(S)-carboxy-3-phenylpropyl)-L-Lys-L-Pro + H2O i.e. MK-522 Rattus norvegicus ?
-
 ?
physalaemin + H2O degraded by striatal and by lung enzyme Rattus norvegicus pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly + Leu-Met-NH2
-
 ?

Subunits

Subunits Comment Organism
? x * 165000, SDS-PAGE Rattus norvegicus