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Literature summary for extracted from

  • Ponndorf, D.; Ehmke, S.; Walliser, B.; Thoss, K.; Unger, C.; Goers, S.; Das, G.; Metges, C.C.; Broer, I.; Nausch, H.
    Stable production of cyanophycinase in Nicotiana benthamiana and its functionality to hydrolyse cyanophycin in the murine intestine (2017), Plant Biotechnol. J., 15, 605-613 .
    View publication on PubMedView publication on EuropePMC


Application Comment Organism
nutrition Nicotiana benthamiana-expressed cyanophycin fed in combination with Nicotiana benthamiana-expressed CGPase is hydrolysed in the intestine of mice, and high levels of beta-Asp-Arg dipeptides are found in plasma. However, there is no increase in Asp and Arg or its metabolite ornithine in plasma. Intestinal degradation of cyanophycin by CGPase leads to low intestinal cyanophycin content 4 h after consumption, but after ingestion of cyanophycin alone, high cyanophycin concentrations remain in the large intestine Thermosynechococcus vestitus

Protein Variants

Protein Variants Comment Organism
additional information optimized transient expression in Nicotiana benthamiana plants to produce high amounts of active CGPase. Protein stability is increased by the translational fusion of CGPase to the green fluorescent protein or to the transit peptide of the small subunit of RuBisCO for peptide production in the chloroplasts Thermosynechococcus vestitus


Organism UniProt Comment Textmining
Thermosynechococcus vestitus P0C8P3

Source Tissue

Source Tissue Comment Organism Textmining


Synonyms Comment Organism
Thermosynechococcus vestitus