Cloned (Comment) | Organism |
---|---|
- |
Escherichia coli |
- |
Streptococcus pneumoniae |
- |
Actinomadura sp. R39 |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(5R,6R)-6-[[(6S)-6-carboxy-6-(glycylamino)hexanoyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | - |
Streptomyces sp. R61 | |
(6R,7R)-3-[(acetyloxy)methyl]-7-[(6S)-6-carboxy-6-(glycylamino)hexanoyl]amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | - |
Streptomyces sp. R61 | |
6-beta(alpha-N-acetyl-L-lysyl)-aminopenicillanic acid | - |
Streptococcus pneumoniae | |
6-beta(D-alpha-aminopimelyl)-aminopenicillanic acid | - |
Actinomadura sp. R39 | |
6-beta(D-alpha-aminopimelyl)-aminopenicillanic acid | - |
Escherichia coli | |
6-beta(D-alpha-aminosuberyl)-aminopenicillanic acid | - |
Actinomadura sp. R39 | |
6-beta(D-alpha-aminosuberyl)-aminopenicillanic acid | - |
Escherichia coli | |
6-beta(N-acetyl-L-alanyl-gamma-D-glutamyl-L-alanyl)-aminopenicillanic acid | - |
Escherichia coli | |
7-beta(alpha-N-acetyl-L-lysyl)-aminocephalosporanic acid | - |
Streptococcus pneumoniae | |
7-beta(D-alpha-aminopimelyl)-aminocephalosporanic acid | - |
Actinomadura sp. R39 | |
7-beta(D-alpha-aminopimelyl)-aminocephalosporanic acid | - |
Escherichia coli | |
benzylpenicillin | - |
Actinomadura sp. R39 | |
benzylpenicillin | - |
Escherichia coli | |
benzylpenicillin | - |
Streptococcus pneumoniae | |
benzylpenicillin | - |
Streptomyces sp. R61 | |
cephalothin | - |
Actinomadura sp. R39 | |
cephalothin | - |
Escherichia coli | |
cephalothin | - |
Streptococcus pneumoniae | |
cephalothin | - |
Streptomyces sp. R61 |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell membrane | attached to the outer leaflet of the cell membrane | Escherichia coli | - |
- |
cell membrane | attached to the outer leaflet of the cell membrane | Streptococcus pneumoniae | - |
- |
cell membrane | attached to the outer leaflet of the cell membrane | Streptomyces sp. R61 | - |
- |
cell membrane | attached to the outer leaflet of the cell membrane | Actinomadura sp. R39 | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Actinomadura sp. R39 | - |
- |
- |
Escherichia coli | - |
- |
- |
Streptococcus pneumoniae | - |
- |
- |
Streptomyces sp. R61 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Escherichia coli |
- |
Streptococcus pneumoniae |
- |
Actinomadura sp. R39 |
Synonyms | Comment | Organism |
---|---|---|
DD-peptidase | - |
Escherichia coli |
DD-peptidase | - |
Streptococcus pneumoniae |
DD-peptidase | - |
Streptomyces sp. R61 |
DD-peptidase | - |
Actinomadura sp. R39 |
PBP 2 | - |
Escherichia coli |
PBP 3 | - |
Streptococcus pneumoniae |
PBP 5 | - |
Escherichia coli |
PBP1b | - |
Streptococcus pneumoniae |
PBP2x | - |
Streptococcus pneumoniae |
penicillin-binding protein | - |
Escherichia coli |
penicillin-binding protein | - |
Streptococcus pneumoniae |
penicillin-binding protein | - |
Streptomyces sp. R61 |
penicillin-binding protein | - |
Actinomadura sp. R39 |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Escherichia coli |
37 | - |
- |
Streptococcus pneumoniae |
37 | - |
- |
Actinomadura sp. R39 |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
- |
Streptococcus pneumoniae |
7.7 | - |
- |
Actinomadura sp. R39 |
8 | - |
- |
Escherichia coli |
8.5 | - |
- |
Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Ki (5R,6R)-6-[[(6S)-6-carboxy-6-(glycylamino)hexanoyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 15000000 s-1 * M-1 | Streptomyces sp. R61 | |
additional information | - |
additional information | Ki (6R,7R)-3-[(acetyloxy)methyl]-7-[(6S)-6-carboxy-6-(glycylamino)hexanoyl]amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 560000 s-1 * M-1 | Streptomyces sp. R61 | |
additional information | - |
additional information | Ki 6-beta(alpha-N-acetyl-L-lysyl)-aminopenicillanic acid, 12000 s-1 * M-1 | Streptococcus pneumoniae | |
additional information | - |
additional information | Ki 6-beta(alpha-N-acetyl-L-lysyl)-aminopenicillanic acid, 3900 s-1 * M-1 | Streptococcus pneumoniae | |
additional information | - |
additional information | Ki 6-beta(alpha-N-acetyl-L-lysyl)-aminopenicillanic acid, 95 s-1 * M-1 | Streptococcus pneumoniae | |
additional information | - |
additional information | Ki 6-beta(D-alpha-aminopimelyl)-aminopenicillanic acid, 6800000 s-1 * M-1 | Actinomadura sp. R39 | |
additional information | - |
additional information | Ki 6-beta(D-alpha-aminosuberyl)-aminopenicillanic acid, 2850000 s-1 * M-1 | Actinomadura sp. R39 | |
additional information | - |
additional information | Ki 7-beta(alpha-N-acetyl-L-lysyl)-aminocephalosporanic acid, 34 s-1 * M-1 | Streptococcus pneumoniae | |
additional information | - |
additional information | Ki 7-beta(D-alpha-aminopimelyl)-aminocephalosporanic acid, 11000000 s-1 * M-1 | Actinomadura sp. R39 | |
additional information | - |
additional information | Ki benzylpenicillin, 13000 s-1 * M-1 | Streptococcus pneumoniae | |
additional information | - |
additional information | Ki benzylpenicillin, 13700 s-1 * M-1 | Streptomyces sp. R61 | |
additional information | - |
additional information | Ki benzylpenicillin, 30000 s-1 * M-1 | Streptococcus pneumoniae | |
additional information | - |
additional information | Ki benzylpenicillin, 300000 s-1 * M-1 | Actinomadura sp. R39 | |
additional information | - |
additional information | Ki cephalothin, 1400 s-1 * M-1 | Streptomyces sp. R61 | |
additional information | - |
additional information | Ki cephalothin, 65000 s-1 * M-1 | Actinomadura sp. R39 | |
additional information | - |
additional information | Ki cephalothin, 91000 s-1 * M-1 | Streptococcus pneumoniae |