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Literature summary for 3.4.17.1 extracted from
- Synthesis and evaluation of alpha,alpha-disubstituted-3-mercaptopropanoic acids as inhibitors for carboxypeptidase A and implications with respect to enzyme inhibitor design (2003), Bioorg. Med. Chem., 11, 4685-4691.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (R)-2-mercaptomethyl-2-methyl-3-phenylpropanoic acid | - |
Bos taurus |  |
| (RS)-2-mercaptomethyl-2-methyl-3-phenylpropanoic acid | - |
Bos taurus | |
| (RS)-2-mercaptomethyl-2-methylbutanoic acid | - |
Bos taurus | |
| (RS)-2-mercaptomethylbutyric acid | - |
Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| hippuryl-L-Phe + H2O | - |
Bos taurus | hippuric acid + L-Phe | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0001 | - |
(RS)-2-mercaptomethylbutyric acid | pH 7.5 | Bos taurus | |
| 0.00011 | - |
(RS)-2-mercaptomethyl-2-methylbutanoic acid | pH 7.5 | Bos taurus | |
| 0.00038 | - |
(RS)-2-mercaptomethyl-2-methyl-3-phenylpropanoic acid | pH 7.5 | Bos taurus | |
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