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Literature summary for 3.4.17.20 extracted from

  • Kokame, K.; Zheng, X.; Sadler, J.E.
    Activation of thrombin-activable fibrinolysis inhibitor requires epidermal growth factor-like domain 3 of thrombomodulin and is inhibited competitively by protein C (1998), J. Biol. Chem., 273, 12135-12139.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Thrombomodulin the epidermal growth factor-like domain 3 of thrombomodulin is required for activation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Fibrin, partially degraded + H2O Homo sapiens the enzyme suppresses the ability of fibrin to catalyze plasminogen activation and thus delays clot lysis ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fibrin, partially degraded + H2O
-
Homo sapiens Fibrin, partially degraded + L-Lys + L-Arg
-
?
Fibrin, partially degraded + H2O the enzyme suppresses the ability of fibrin to catalyze plasminogen activation and thus delays clot lysis Homo sapiens ?
-
?