BRENDA - Enzyme Database
show all sequences of 3.4.17.23

A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9

Donoghue, M.; Hsieh, F.; Baronas, E.; Godbout, K.; Gosselin, M.; Stagliano, N.; Donovan, M.; Woolf, B.; Robison, K.; Jeyaseelan, R.; Breitbart, R.E.; Acton, S.; Circ. Res. 87, E1-9 (2000)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
gene ACE2, DNA sequence determination and analysis, expression in CHO K1 cells, secretion of the active enzyme from transfected cells by cleavage N-terminal to the transmembrane domain
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
no inhibition by captopril
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
enzyme possesses a transmembrane domain, posttranslational cleavage for secretion of the protein in vivo and in cell culture
Homo sapiens
16020
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
additional information
metalloprotease
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
angiotensin I + H2O
Homo sapiens
-
angiotensin-(1-9) + Leu
-
-
-
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
Q9BYF1
-
-
Purification (Commentary)
Purification (Commentary)
Organism
recombinant from CHO K1 cells
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
epithelium
of coronary and intrarenal vessels and renal tubuls
Homo sapiens
-
heart ventricle
-
Homo sapiens
-
testis
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
angiotensin I + H2O
-
658455
Homo sapiens
angiotensin-(1-9) + Leu
-
-
-
-
angiotensin I + H2O
no angiotensin-converting activity, i.e. no conversion of the decapeptide angiotensin I to the octapeptide angiotensin II
658455
Homo sapiens
angiotensin-(1-9) + Leu
-
-
-
-
Synonyms
Synonyms
Commentary
Organism
ACE-related carboxypeptidase
-
Homo sapiens
ACE2
-
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
gene ACE2, DNA sequence determination and analysis, expression in CHO K1 cells, secretion of the active enzyme from transfected cells by cleavage N-terminal to the transmembrane domain
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
no inhibition by captopril
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
enzyme possesses a transmembrane domain, posttranslational cleavage for secretion of the protein in vivo and in cell culture
Homo sapiens
16020
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
additional information
metalloprotease
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
angiotensin I + H2O
Homo sapiens
-
angiotensin-(1-9) + Leu
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant from CHO K1 cells
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
epithelium
of coronary and intrarenal vessels and renal tubuls
Homo sapiens
-
heart ventricle
-
Homo sapiens
-
testis
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
angiotensin I + H2O
-
658455
Homo sapiens
angiotensin-(1-9) + Leu
-
-
-
-
angiotensin I + H2O
no angiotensin-converting activity, i.e. no conversion of the decapeptide angiotensin I to the octapeptide angiotensin II
658455
Homo sapiens
angiotensin-(1-9) + Leu
-
-
-
-
Other publictions for EC 3.4.17.23
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)