Data extracted from this reference:
Cloned(Commentary)
gene ACE2, DNA sequence determination and analysis, expression in CHO K1 cells, secretion of the active enzyme from transfected cells by cleavage N-terminal to the transmembrane domain
Homo sapiens
Inhibitors
additional information
no inhibition by captopril
Homo sapiens
Localization
membrane
enzyme possesses a transmembrane domain, posttranslational cleavage for secretion of the protein in vivo and in cell culture
Homo sapiens
16020
Metals/Ions
additional information
metalloprotease
Homo sapiens
Natural Substrates/ Products (Substrates)
angiotensin I + H2O
Homo sapiens
angiotensin-(1-9) + Leu
Organism
Purification (Commentary)
recombinant from CHO K1 cells
Homo sapiens
Source Tissue
epithelium
of coronary and intrarenal vessels and renal tubuls
Homo sapiens
heart ventricle
Homo sapiens
Substrates and Products (Substrate)
angiotensin I + H2O
658455
Homo sapiens
angiotensin-(1-9) + Leu
angiotensin I + H2O
no angiotensin-converting activity, i.e. no conversion of the decapeptide angiotensin I to the octapeptide angiotensin II
658455
Homo sapiens
angiotensin-(1-9) + Leu
Synonyms
ACE-related carboxypeptidase
Homo sapiens
Cloned(Commentary) (protein specific)
gene ACE2, DNA sequence determination and analysis, expression in CHO K1 cells, secretion of the active enzyme from transfected cells by cleavage N-terminal to the transmembrane domain
Homo sapiens
Inhibitors (protein specific)
additional information
no inhibition by captopril
Homo sapiens
Localization (protein specific)
membrane
enzyme possesses a transmembrane domain, posttranslational cleavage for secretion of the protein in vivo and in cell culture
Homo sapiens
16020
Metals/Ions (protein specific)
additional information
metalloprotease
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
angiotensin I + H2O
Homo sapiens
angiotensin-(1-9) + Leu
Purification (Commentary) (protein specific)
recombinant from CHO K1 cells
Homo sapiens
Source Tissue (protein specific)
epithelium
of coronary and intrarenal vessels and renal tubuls
Homo sapiens
heart ventricle
Homo sapiens
Substrates and Products (Substrate) (protein specific)
angiotensin I + H2O
658455
Homo sapiens
angiotensin-(1-9) + Leu
angiotensin I + H2O
no angiotensin-converting activity, i.e. no conversion of the decapeptide angiotensin I to the octapeptide angiotensin II
658455
Homo sapiens
angiotensin-(1-9) + Leu
Other publictions for EC 3.4.17.23