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Literature summary for 3.4.17.23 extracted from

  • Tipnis, S.R.; Hooper, N.M.; Hyde, R.J.; Christie, G.; Karran, E.; Turner, A.J.
    A humen homolog of angiotensin converting enzyme - cloning and functional expression as a captopril-insensitive carboxypeptidase (2000), J. Biol. Chem., 275, 33238-33243.
    View publication on PubMed
Search for more literature for 3.4.17.23

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination, gene maps to choromosomal location Xp22, expression in CHO cells of the wild-type and of the soluble truncated mutant, the latter as c-Myc- and His-tagged protein Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of a soluble truncated mutant enzyme lacking the transmembrane and cytosolic domains Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
EDTA no inhibition by benzylsuccinate, no inhibition by lisinopril, no inhibition by captopril, no inhibition by enalaprilat Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc-binding motif HEXXH and third zinc ligand glutamate402, contains zinc-binding consensus sequence HEXXH, amino acids 374-378, zinc-binding protease Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
92460
-
 DNA sequence determination Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Homo sapiens
-
 angiotensin-(1-9) + Leu
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYF1
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein 7 potential N-glycosylation sites Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
colon only moderate levels Homo sapiens
-
heart
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
ovary only moderate levels Homo sapiens
-
small intestine only moderate levels Homo sapiens
-
testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
 Homo sapiens angiotensin-(1-9) + Leu
-
 ?
angiotensin I + H2O wild-type and truncated mutant Homo sapiens angiotensin-(1-9) + Leu
-
 ?
angiotensin II + H2O wild-type and truncated mutant Homo sapiens angiotensin-(1-7) + Phe
-
 ?

Synonyms

Synonyms Comment Organism
ACEH
-
 Homo sapiens
angiotensin-converting enzyme homolog
-
 Homo sapiens
angiotensin-converting enzyme-like protein
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens