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Literature summary for 3.4.17.23 extracted from

  • Rice, G.I.; Thomas, D.A.; Grant, P.J.; Turner, A.J.; Hooper, N.M.
    Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism (2004), Biochem. J., 383, 45-51.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
additional information carboxylalkyl compounds cilazaprilat, indolaprilat, perindoprilat, quinaprilat and spiraprilat, the thiol compounds rentiapril and zofenapril, and the phosphoryl compounds ceranopril and fosinoprilat fail to inhibit the hydrolysis of either angiotensin I or angiotensin II by ACE2 at concentrations that abolished activity of EC 3.4.15.1 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0057
-
angiotensin II 37°C, pH 7.4 Homo sapiens
0.0868
-
angiotensin I 37°C, pH 7.4 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
recombinant
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
Homo sapiens angiotensin-(1-9) + Leu
-
?
angiotensin II + H2O
-
Homo sapiens angiotensin-(1-7) + Phe
-
?
additional information no activity with angiotensin (1-9) and angiotensin(1-7) Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ACE2
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.9
-
angiotensin I 37°C, pH 7.4 Homo sapiens
12.8
-
angiotensin II 37°C, pH 7.4 Homo sapiens