Inhibitors | Comment | Organism | Structure |
---|---|---|---|
angiotensin I | - |
Homo sapiens | |
DX600 | IC50: 10 nM | Homo sapiens | |
MLN-4760 | i.e. (SS) 2-[(1)-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl]ethylamino]-4-methyl-pentanoic acid, IC50: 0.44 nM | Homo sapiens | |
Pro-Phe | IC50: 0.15 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is involved in diesease condition including hypertension, diabetes and cardiac function. ACE2 is the SARS virus receptor | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | - |
Homo sapiens | angiotensin-(1-9) + Leu | - |
? | |
angiotensin II + H2O | - |
Homo sapiens | angiotensin-(1-7) + Phe | - |
? | |
angiotensin IV + H2O | - |
Homo sapiens | VYIHP + Phe | - |
? | |
apelin-13 + H2O | - |
Homo sapiens | QRPRLSHKGPMP + Phe | - |
? | |
apelin-36 + H2O | - |
Homo sapiens | ? | - |
? | |
beta-casomorphin + H2O | - |
Homo sapiens | YPFVEP + Ile | - |
? | |
des-Arg9-bradykinin + H2O | - |
Homo sapiens | RPPGFSP + Phe | - |
? | |
dynorphin A(1-13) + H2O | - |
Homo sapiens | YGGFLRRIRPKL + Lys | - |
? | |
ghrelin + H2O | - |
Homo sapiens | ? | - |
? | |
Lys-des-Arg9 bradykinin + H2O | - |
Homo sapiens | KRPPGFSP + Phe | - |
? | |
additional information | the enzyme is involved in diesease condition including hypertension, diabetes and cardiac function. ACE2 is the SARS virus receptor | Homo sapiens | ? | - |
? | |
additional information | no hydrolysis of angiotensin (1-9), angiotensin (1-7), bradikinin, bradykinin(1-7), neurotensin(1-13) | Homo sapiens | ? | - |
? | |
neurotensin(1-11) + H2O | - |
Homo sapiens | pELYENKPRRP + Tyr | - |
? | |
neurotensin(1-8) + H2O | - |
Homo sapiens | pELYENKP + Arg | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACE2 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000028 | - |
DX600 | - |
Homo sapiens | |
0.0022 | - |
angiotensin I | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00000044 | - |
i.e. (SS) 2-[(1)-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl]ethylamino]-4-methyl-pentanoic acid, IC50: 0.44 nM | Homo sapiens | MLN-4760 | |
0.00001 | - |
IC50: 10 nM | Homo sapiens | DX600 | |
0.15 | - |
IC50: 0.15 mM | Homo sapiens | Pro-Phe |