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Literature summary for 3.4.17.23 extracted from

  • Warner, F.J.; Smith, A.I.; Hooper, N.M.; Turner, A.J.
    Angiotensin-converting enzyme-2: a molecular and cellular perspective (2004), Cell. Mol. Life Sci., 61, 2704-2713.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
angiotensin I
-
Homo sapiens
DX600 IC50: 10 nM Homo sapiens
MLN-4760 i.e. (SS) 2-[(1)-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl]ethylamino]-4-methyl-pentanoic acid, IC50: 0.44 nM Homo sapiens
Pro-Phe IC50: 0.15 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is involved in diesease condition including hypertension, diabetes and cardiac function. ACE2 is the SARS virus receptor ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
Homo sapiens angiotensin-(1-9) + Leu
-
?
angiotensin II + H2O
-
Homo sapiens angiotensin-(1-7) + Phe
-
?
angiotensin IV + H2O
-
Homo sapiens VYIHP + Phe
-
?
apelin-13 + H2O
-
Homo sapiens QRPRLSHKGPMP + Phe
-
?
apelin-36 + H2O
-
Homo sapiens ?
-
?
beta-casomorphin + H2O
-
Homo sapiens YPFVEP + Ile
-
?
des-Arg9-bradykinin + H2O
-
Homo sapiens RPPGFSP + Phe
-
?
dynorphin A(1-13) + H2O
-
Homo sapiens YGGFLRRIRPKL + Lys
-
?
ghrelin + H2O
-
Homo sapiens ?
-
?
Lys-des-Arg9 bradykinin + H2O
-
Homo sapiens KRPPGFSP + Phe
-
?
additional information the enzyme is involved in diesease condition including hypertension, diabetes and cardiac function. ACE2 is the SARS virus receptor Homo sapiens ?
-
?
additional information no hydrolysis of angiotensin (1-9), angiotensin (1-7), bradikinin, bradykinin(1-7), neurotensin(1-13) Homo sapiens ?
-
?
neurotensin(1-11) + H2O
-
Homo sapiens pELYENKPRRP + Tyr
-
?
neurotensin(1-8) + H2O
-
Homo sapiens pELYENKP + Arg
-
?

Synonyms

Synonyms Comment Organism
ACE2
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000028
-
DX600
-
Homo sapiens
0.0022
-
angiotensin I
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000044
-
i.e. (SS) 2-[(1)-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl]ethylamino]-4-methyl-pentanoic acid, IC50: 0.44 nM Homo sapiens MLN-4760
0.00001
-
IC50: 10 nM Homo sapiens DX600
0.15
-
IC50: 0.15 mM Homo sapiens Pro-Phe