Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.17.23 extracted from

  • Ferrario, C.M.
    Angiotensin-converting enzyme 2 and angiotensin-(1-7): an evolving story in cardiovascular regulation (2006), Hypertension, 47, 515-521.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin II + H2O Rattus norvegicus ACE2 is highly regulated at transcription. ACE2 plays a critical role in regulating the balance between vasoconstrictor and vasodilator effects within the RAS cascade. Angiotensin II may be a stimulus determining cardiac ACE2 gene expression, because either reduction in its levels or prevention of angiotensin II binding to the AT1 receptor increases ACE2 mRNA. ACE2 serves as the cellular entry point for severe acute respiratory syndrome (SARS) virus angiotensin-(1-7) + Phe
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain stem about 20% of the ACE2 gene expression in kidney cortex Rattus norvegicus
-
cerebral cortex about 10% of the ACE2 gene expression in kidney cortex Rattus norvegicus
-
heart about 35% of the ACE2 gene expression in kidney cortex Rattus norvegicus
-
hypothalamus about 15% of the ACE2 gene expression in kidney cortex Rattus norvegicus
-
kidney cortex and medulla, about 50% of the ACE2 gene expression in kidney cortex Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin II + H2O ACE2 is highly regulated at transcription. ACE2 plays a critical role in regulating the balance between vasoconstrictor and vasodilator effects within the RAS cascade. Angiotensin II may be a stimulus determining cardiac ACE2 gene expression, because either reduction in its levels or prevention of angiotensin II binding to the AT1 receptor increases ACE2 mRNA. ACE2 serves as the cellular entry point for severe acute respiratory syndrome (SARS) virus Rattus norvegicus angiotensin-(1-7) + Phe
-
?