Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin II + H2O | Rattus norvegicus | ACE2 is highly regulated at transcription. ACE2 plays a critical role in regulating the balance between vasoconstrictor and vasodilator effects within the RAS cascade. Angiotensin II may be a stimulus determining cardiac ACE2 gene expression, because either reduction in its levels or prevention of angiotensin II binding to the AT1 receptor increases ACE2 mRNA. ACE2 serves as the cellular entry point for severe acute respiratory syndrome (SARS) virus | angiotensin-(1-7) + Phe | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain stem | about 20% of the ACE2 gene expression in kidney cortex | Rattus norvegicus | - |
cerebral cortex | about 10% of the ACE2 gene expression in kidney cortex | Rattus norvegicus | - |
heart | about 35% of the ACE2 gene expression in kidney cortex | Rattus norvegicus | - |
hypothalamus | about 15% of the ACE2 gene expression in kidney cortex | Rattus norvegicus | - |
kidney | cortex and medulla, about 50% of the ACE2 gene expression in kidney cortex | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin II + H2O | ACE2 is highly regulated at transcription. ACE2 plays a critical role in regulating the balance between vasoconstrictor and vasodilator effects within the RAS cascade. Angiotensin II may be a stimulus determining cardiac ACE2 gene expression, because either reduction in its levels or prevention of angiotensin II binding to the AT1 receptor increases ACE2 mRNA. ACE2 serves as the cellular entry point for severe acute respiratory syndrome (SARS) virus | Rattus norvegicus | angiotensin-(1-7) + Phe | - |
? |