Literature summary for 3.4.17.23 extracted from

Xia, H.; Lazartigues, E.
Angiotensin-converting enzyme 2 in the brain: properties and future directions (2008), J. Neurochem., 107, 1482-1494.

Search for more literature for 3.4.17.23

Cloned(Commentary)

Cloned (Comment)	Organism
development of a transgenic mouse model (syn-hACE2) where the full open reading frame of the human ACE2 gene is under the control of a synapsin promoter, allowing the hACE2 protein to be expressed specifically in neurons	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	metallopeptidase	Homo sapiens
Zn2+	metallopeptidase	Mus musculus
Zn2+	metallopeptidase	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
angiotensin II + H2O	Homo sapiens	the major role of ACE2 in Ang peptides metabolism is the production of Ang-(1-7). ACE2 also participates in the metabolism of other peptides non related to the renin-angiotensin system: apelin-13, neurotensin, kinetensin, dynorphin, [des-Arg9]-bradykinin, and [Lys-des-Arg9]-bradykinin	angiotensin-(1-7) + Phe	-	?
additional information	Homo sapiens	the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BYF1	-	-
Mus musculus	Q8R0I0	-	-
Rattus norvegicus	Q5EGZ1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
brain	ACE2 is widespread throughout the brain, present in nuclei involved in the central regulation of cardiovascular function like the cardio-respiratory neurons of the brainstem, as well as in non-cardiovascular areas such as the motor cortex and raphe	Homo sapiens	-
brain	predominantly in neurons	Mus musculus	-
kidney	in salt-sensitive Sabra hypertensive (SBH/y) rats, ACE2 mRNA and protein expression are lower than that in salt-resistant Sabra normotensive (SBN/y) rats	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
angiotensin I + H2O	the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited	Homo sapiens	angiotensin-(1-9) + Leu	-	?
angiotensin II + H2O	-	Mus musculus	angiotensin-(1-7) + Phe	-	?
angiotensin II + H2O	-	Rattus norvegicus	angiotensin-(1-7) + Phe	-	?
angiotensin II + H2O	the major role of ACE2 in Ang peptides metabolism is the production of Ang-(1-7). ACE2 also participates in the metabolism of other peptides non related to the renin-angiotensin system: apelin-13, neurotensin, kinetensin, dynorphin, [des-Arg9]-bradykinin, and [Lys-des-Arg9]-bradykinin	Homo sapiens	angiotensin-(1-7) + Phe	-	?
angiotensin II + H2O	ACE2 has approximately a 400fold greater affinity for Ang-II than Ang-I	Homo sapiens	angiotensin-(1-7) + Phe	-	?
additional information	the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited	Homo sapiens	?	-	?
additional information	hydrolyses its substrates by removing a single amino acid from their respective C-terminal	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
ACE 2	-	Homo sapiens
ACE 2	-	Mus musculus
ACE 2	-	Rattus norvegicus
Ang converting enzyme 2	-	Homo sapiens
Ang converting enzyme 2	-	Mus musculus
Ang converting enzyme 2	-	Rattus norvegicus
angiotensin converting enzyme 2	-	Homo sapiens
angiotensin converting enzyme 2	-	Mus musculus
angiotensin converting enzyme 2	-	Rattus norvegicus
hACE2	-	Homo sapiens

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Release 2023.1 (January 2023)