Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | ACE2 exists as bothmembrane bound and soluble forms, the latter being generated by proteolytic cleavage of the ectodomain by the tumor necrosis factor convertase ADAM17 | Homo sapiens | 5737 | - |
membrane | ACE2 exists as bothmembrane bound and soluble forms, the latter being generated by proteolytic cleavage of the ectodomain by the tumor necrosis factor convertase ADAM17 | Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc metalloprotease | Homo sapiens | |
Zn2+ | zinc metalloprotease | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BYF1 | - |
- |
Rattus norvegicus | Q5EGZ1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | - |
Rattus norvegicus | - |
brain | - |
Rattus norvegicus | - |
colon | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
kidney | localization of ACE2 in the podocytes early in the development of diabetes indicates that it may protect against podocyte loss, thus preventing the worsening glomerular injury | Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
lung | - |
Rattus norvegicus | - |
ovary | - |
Homo sapiens | - |
pancreas | ACE-mediated inhibition of TGF-beta expression may prevent islet fibrosis and loss of islet function | Rattus norvegicus | - |
placenta | - |
Homo sapiens | - |
retina | - |
Homo sapiens | - |
retina | - |
Rattus norvegicus | - |
small intestine | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ACE2 | - |
Homo sapiens |
ACE2 | - |
Rattus norvegicus |