Application | Comment | Organism |
---|---|---|
medicine | enhancing ACE2 action may serve to provide additional therapeutic benefits patients with cardiovascular and diabetic kidney disease. Increased ACE2 activity by the use of human recombinant ACE2 and/or a small molecule activator(xanthenone) of ACE2 may represent potential new therapies for lung, cardiovascular and kidney diseases by providing dual beneficial effects by antagonizing angiotensin II action while generating angiotensin-(1-7) | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | ACE2 plays a key role in pulmonary, cardiovascular and hypertensive and diabetic kidney diseases. ACE2 plays a pivotal role in maintaining a balanced status of the RAS synergistically with ACE by exerting counter-regulatory effects | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BYF1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | the endothelium-bound carboxypeptidase is expressed in the heart and kidney | Homo sapiens | - |
kidney | the endothelium-bound carboxypeptidases is expressed in the heart and kidney. ACE2 is expressed in renal tubular epithelium, vascular smooth muscle cells of the intrarenal arteries and in the glomeruli | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | - |
Homo sapiens | angiotensin-(1-9) + Leu | - |
? | |
angiotensin II + H2O | - |
Homo sapiens | angiotensin-(1-7) + Phe | - |
? | |
additional information | ACE2 plays a key role in pulmonary, cardiovascular and hypertensive and diabetic kidney diseases. ACE2 plays a pivotal role in maintaining a balanced status of the RAS synergistically with ACE by exerting counter-regulatory effects | Homo sapiens | ? | - |
? | |
additional information | ACE2 functions predominantly as a carboxymonopeptidase with a substrate preference for hydrolysis between proline and a hydrophobic or basic C-terminal residue | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACE2 | - |
Homo sapiens |
angiotensin converting enzyme 2 | - |
Homo sapiens |