BRENDA - Enzyme Database
show all sequences of 3.4.17.23

Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2

Masson, R.; Nicklin, S.A.; Craig, M.A.; McBride, M.; Gilday, K.; Gregorevic, P.; Allen, J.M.; Chamberlain, J.S.; Smith, G.; Graham, D.; Dominiczak, A.F.; Napoli, C.; Baker, A.H.; Hypertension 53, 694-700 (2009)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
overexpression of ACE2, by usage of a recombinant adeno-associated virus 6 delivery system, in myocardium of stroke-prone spontaneously hypertensive rats, gene expression profiling, overview
Rattus norvegicus
Engineering
Protein Variants
Commentary
Organism
additional information
ACE2 overexpression leads to markedly increased myocyte volume, assessed in primary rabbit myocytes
Oryctolagus cuniculus
additional information
overexpression of ACE2, by usage of a recombinant adeno-associated virus 6 delivery system, in myocardium of stroke-prone spontaneously hypertensive rats mediates onset of experimental severe cardiac fibrosis
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
angiotensin II + H2O
Rattus norvegicus
-
angiotensin(1-7) + L-Phe
-
-
?
angiotensin II + H2O
Oryctolagus cuniculus
-
angiotensin(1-7) + L-Phe
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
cell culture
-
Oryctolagus cuniculus
-
heart
-
Rattus norvegicus
-
heart
-
Oryctolagus cuniculus
-
myocardium
-
Rattus norvegicus
-
myocyte
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
angiotensin II + H2O
-
708684
Rattus norvegicus
angiotensin(1-7) + L-Phe
-
-
-
?
angiotensin II + H2O
-
708684
Oryctolagus cuniculus
angiotensin(1-7) + L-Phe
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
ACE2
-
Oryctolagus cuniculus
Cloned(Commentary) (protein specific)
Commentary
Organism
overexpression of ACE2, by usage of a recombinant adeno-associated virus 6 delivery system, in myocardium of stroke-prone spontaneously hypertensive rats, gene expression profiling, overview
Rattus norvegicus
Engineering (protein specific)
Protein Variants
Commentary
Organism
additional information
ACE2 overexpression leads to markedly increased myocyte volume, assessed in primary rabbit myocytes
Oryctolagus cuniculus
additional information
overexpression of ACE2, by usage of a recombinant adeno-associated virus 6 delivery system, in myocardium of stroke-prone spontaneously hypertensive rats mediates onset of experimental severe cardiac fibrosis
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
angiotensin II + H2O
Rattus norvegicus
-
angiotensin(1-7) + L-Phe
-
-
?
angiotensin II + H2O
Oryctolagus cuniculus
-
angiotensin(1-7) + L-Phe
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
cell culture
-
Oryctolagus cuniculus
-
heart
-
Rattus norvegicus
-
heart
-
Oryctolagus cuniculus
-
myocardium
-
Rattus norvegicus
-
myocyte
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
angiotensin II + H2O
-
708684
Rattus norvegicus
angiotensin(1-7) + L-Phe
-
-
-
?
angiotensin II + H2O
-
708684
Oryctolagus cuniculus
angiotensin(1-7) + L-Phe
-
-
-
?
General Information
General Information
Commentary
Organism
physiological function
role of ACE2 in the regulation of cardiac structure and function, as well as maintenance of systemic blood pressure, overview
Oryctolagus cuniculus
General Information (protein specific)
General Information
Commentary
Organism
physiological function
role of ACE2 in the regulation of cardiac structure and function, as well as maintenance of systemic blood pressure, overview
Oryctolagus cuniculus
Other publictions for EC 3.4.17.23
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)