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Literature summary for 3.4.17.23 extracted from

  • Fraga-Silva, R.A.; Sorg, B.S.; Wankhede, M.; Dedeugd, C.; Jun, J.Y.; Baker, M.B.; Li, Y.; Castellano, R.K.; Katovich, M.J.; Raizada, M.K.; Ferreira, A.J.
    ACE2 activation promotes antithrombotic activity (2010), Mol. Med., 16, 210-215.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.17.23

Activating Compound

Activating Compound Comment Organism Structure
XNT activates ACE2, reduces platelet attachment to injured vessels, reduces thrombus size, and prolonges the time for complete vessel occlusion in mice. Thrombus area is reduced by 60%, whereas time for thrombus formation is prolonged by 45% in XNT-treated mice Mus musculus
XNT treatment at 10 mg/kg resultes in a 30% attenuation of thrombus formation in the SHR Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
DX600 a decrease in thrombus ACE2 activity is associated with increased thrombus formation in nude mice Mus musculus
DX600 a decrease in thrombus ACE2 activity is associated with increased thrombus formation in spontaneously hypertensive rats Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
 Mus musculus
Zn2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin II + H2O Mus musculus angiotensin II has many adverse cardiovascular effects when acting through the AT1 receptor angiotensin(1-7) + L-Phe
-
 ?
angiotensin II + H2O Rattus norvegicus angiotensin II has many adverse cardiovascular effects when acting through the AT1 receptor angiotensin(1-7) + L-Phe
-
 ?
additional information Mus musculus ACE2 activation promotes antithrombotic activity. ACE2 is an ACE, EC 3.4.15.1, homologue ?
-
 ?
additional information Rattus norvegicus ACE2 activation promotes antithrombotic activity. ACE2 is an ACE, EC 3.4.15.1, homologue ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 nude mice
-
Rattus norvegicus
-
 spontaneously hypertensive rats and Wistar Kyoto rats
-

Source Tissue

Source Tissue Comment Organism Textmining
blood vessel
-
 Mus musculus
-
blood vessel
-
 Rattus norvegicus
-
skin
-
 Mus musculus
-
skin
-
 Rattus norvegicus
-
vena cava induced thrombus Mus musculus
-
vena cava induced thrombus. No differences between spontaneously hypertensive rats and Wistar Kyoto rats in ACE2 protein and ACE activity in the thrombi Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-methoxycoumarin-4-acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(2,4-dinitrophenyl)-OH + H2O
-
 Mus musculus ?
-
 ?
7-methoxycoumarin-4-acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(2,4-dinitrophenyl)-OH + H2O
-
 Rattus norvegicus ?
-
 ?
7-methoxycoumarin-4-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys-(2,4-dinitrophenyl)-OH + H2O
-
 Mus musculus ?
-
 ?
7-methoxycoumarin-4-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys-(2,4-dinitrophenyl)-OH + H2O
-
 Rattus norvegicus ?
-
 ?
angiotensin II + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Mus musculus angiotensin(1-7) + L-Phe i.e. Asp-Arg-Val-Tyr-Ile-His-Pro ?
angiotensin II + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Rattus norvegicus angiotensin(1-7) + L-Phe i.e. Asp-Arg-Val-Tyr-Ile-His-Pro ?
angiotensin II + H2O angiotensin II has many adverse cardiovascular effects when acting through the AT1 receptor Mus musculus angiotensin(1-7) + L-Phe
-
 ?
angiotensin II + H2O angiotensin II has many adverse cardiovascular effects when acting through the AT1 receptor Rattus norvegicus angiotensin(1-7) + L-Phe
-
 ?
additional information ACE2 activation promotes antithrombotic activity. ACE2 is an ACE, EC 3.4.15.1, homologue Mus musculus ?
-
 ?
additional information ACE2 activation promotes antithrombotic activity. ACE2 is an ACE, EC 3.4.15.1, homologue Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
ACE2
-
 Mus musculus
ACE2
-
 Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Mus musculus
7.5
-
 assay at Rattus norvegicus