Literature summary for 3.4.17.23 extracted from

Han, S.X.; He, G.M.; Wang, T.; Chen, L.; Ning, Y.Y.; Luo, F.; An, J.; Yang, T.; Dong, J.J.; Liao, Z.L.; Xu, D.; Wen, F.Q.
Losartan attenuates chronic cigarette smoke exposure-induced pulmonary arterial hypertension in rats: possible involvement of angiotensin-converting enzyme-2 (2010), Toxicol. Appl. Pharmacol., 245, 100-107.

Search for more literature for 3.4.17.23

Activating Compound

Activating Compound	Comment	Organism	Structure
losartan	a specific angiotensin II receptor antagonist, is a well-known antihypertensive drug with a potential role in positively regulating ACE2 in the lung	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
DX600	-	Rattus norvegicus
additional information	chronic cigarette smoke administration causes an reduction in ACE2 activity and increases angiotensin II levels in the lung	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
angiotensin II + H2O	Rattus norvegicus	high levels of angiotensin II induces pulmonary arterial hypertension	angiotensin(1-7) + L-Phe	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male sprague-dawley rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cell culture	-	Rattus norvegicus	-
lung	-	Rattus norvegicus	-
pulmonary artery smooth muscle cell	primary cell culture	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
angiotensin II + H2O	-	Rattus norvegicus	angiotensin(1-7) + L-Phe	-	?
angiotensin II + H2O	high levels of angiotensin II induces pulmonary arterial hypertension	Rattus norvegicus	angiotensin(1-7) + L-Phe	-	?

Synonyms

Synonyms	Comment	Organism
ACE2	-	Rattus norvegicus
angiotensin-converting enzyme-2	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	ACE2 is a regulator of the renin-angiotensin system,. Losartan, a specific angiotensin II receptor antagonist, is a well-known antihypertensive drug with a potential role in regulating ACE2	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)