Literature summary for 3.4.17.23 extracted from

Cao, X.; Song, L.; Zhang, Y.; Li, Q.; Shi, T.; Yang, F.; Yuan, M.; Xin, Z.; Yang, J.
Angiotensin-converting enzyme 2 inhibits endoplasmic reticulum stress-associated pathway to preserve nonalcoholic fatty liver disease (2019), Diabetes Metab. Res. Rev., 35, e3123 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BYF1	-	-
Mus musculus	Q8R0I0	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	-	Homo sapiens	-
liver	-	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	ACE2 is significantly increased in thapsigargin or palmitic acid-induced cultured hepatocytes. Activation of ACE2 can ameliorate ER stress, accompanied by decreased thapsigargin content, increased intracellular glycogen, and downregulated expression of hepatic lipogenic proteins and enzymes for gluconeogenesis in thapsigargin or palmitic acid-induced hepatocytes	Homo sapiens
physiological function	ACE2 knockout mice display elevated levels of ER stress, while ACE2 overexpressing db/db mice show reduced ER stress in liver	Mus musculus

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Release 2023.1 (January 2023)