Literature summary for 3.4.17.23 extracted from

Cao, X.; Yang, F.; Shi, T.; Yuan, M.; Xin, Z.; Xie, R.; Li, S.; Li, H.; Yang, J.K.
Angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis activates Akt signaling to ameliorate hepatic steatosis (2016), Sci. Rep., 6, 21592 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BYF1	-	-
Mus musculus	Q8R0I0	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	-	Homo sapiens	-
liver	-	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	angiotensin (1-7)/ACE2 ameliorate hepatic steatosis, oxidative stress and inflammation in free fatty acid-induced Hep-G2 cells, and Akt inhibitors reduce ACE2-mediated lipid metabolism. The ACE2-mediated Akt activation can be attenuated by blockade of ATP/P2 receptor/Calmodulin (CaM) pathway	Homo sapiens
physiological function	deletion of ACE2 aggravates liver steatosis, which is correlated with the increased expression of hepatic lipogenic genes and the decreased expression of fatty acid oxidation-related genes in the liver of ACE2 knockout mice. Oxidative stress and inflammation are also aggravated in ACE2 knockout mice. Overexpression of ACE2 improves fatty liver in db/db mice, and the mRNA levels of fatty acid oxidation-related genes are up-regulated	Mus musculus

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Release 2023.1 (January 2023)