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Literature summary for 3.4.19.12 extracted from
- Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins (2000), J. Biol. Chem., 275, 14212-14216.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene usp21, DNA sequence determination and analysis, located on chromosome 1q21, expression in COS cells, overexpression in U2O2 cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C37A | site-directed mutagenesis | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ubiquitin-protein + H2O | Homo sapiens | important role in regulation of cell growth | ubiquitin + protein | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9UK80 | gene usp21, dual substrate specificity for ubiquitin- and NEDD8-conjugates | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | usp21 gene expression | Homo sapiens | - |
| heart | usp21 gene expression, high content | Homo sapiens | - |
| kidney | usp21 gene expression | Homo sapiens | - |
| liver | usp21 gene expression | Homo sapiens | - |
| pancreas | usp21 gene expression, high content | Homo sapiens | - |
| placenta | usp21 gene expression | Homo sapiens | - |
| skeletal muscle | usp21 gene expression | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | no activity with Sentrin-1-conjugates | Homo sapiens | ? | - |
? | |
| NEDD8-protein + H2O | enzyme shows dual specificity for ubiquitin-conjugates and NEDD8-conjugates | Homo sapiens | NEDD8 + protein | - |
? | |
| ubiquitin-protein + H2O | enzyme shows dual specificity for ubiquitin-conjugates and NEDD8-conjugates | Homo sapiens | ubiquitin + protein | - |
? | |
| ubiquitin-protein + H2O | important role in regulation of cell growth | Homo sapiens | ubiquitin + protein | - |
? | |
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Release 2023.1 (January 2023)
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