Cloned (Comment) | Organism |
---|---|
expressiom of GFP-tagged wild-type UCH L1 and mutants in PC12 Tet-off cells and in CHO-AA8-Luc1 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C90S | site-directed mutagenesis, the mutant enzyme lacks C-terminal hydrolase activity but retains ubiquitin binding activity, the mutant shows similar physiological effects in recombinant transfected cells as the wild-type enzyme, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | ubiquitin carboxy-terminal hydrolase L1 activates the P2X receptor leading to potentiation of ATP-induced currents in neurons | ? | - |
? | |
additional information | Rattus norvegicus | overexpression of UCH L1 potentiates ATP-induced currents due to the activation of P2X receptors that are widely distributed in the brain and involved in various biological activities including neurosecretion. UCH-L1 may play an important role in synaptic activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
neuron | - |
Homo sapiens | - |
PC-12 cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | ubiquitin carboxy-terminal hydrolase L1 activates the P2X receptor leading to potentiation of ATP-induced currents in neurons | Homo sapiens | ? | - |
? | |
additional information | overexpression of UCH L1 potentiates ATP-induced currents due to the activation of P2X receptors that are widely distributed in the brain and involved in various biological activities including neurosecretion. UCH-L1 may play an important role in synaptic activity | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin carboxy-terminal hydrolase L1 | - |
Homo sapiens |
UCH L1 | - |
Homo sapiens |