Application | Comment | Organism |
---|---|---|
medicine | UCH-L1 is selectively expressed on the plasma membrane of mouse ova, where it may regulate membrane penetration by spermatozoa. The unique expression patterns of UCH-L1 and UCH-L3 suggest that these proteins have distinct functions during oogenesis and embryogenesis. UCH-L1 functions in the polyspermy block during mammalian fertilization | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | UCH-L1-deficient ova of gad female mice have a significantly increased rate of polyspermy in in vitro fertilization assays, although the rate of fertilization does not differ significantly from wild-type mice. Litter size of gad female mice is significantly reduced compared with wild-type mice | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | UCH-L3 concentrated in the cytoplasm of oocytes and developing embryos | Mus musculus | 5737 | - |
plasma membrane | UCH-L1 most abundant at the plasma membrane of oocytes in developing follicles and in developing embryos | Mus musculus | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
BDF1, gad (CBA/RFM) and Uchl3 knockout (C57BL/6J) female and male mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blastocyst | UCH-L1 present in the outer layer cells of the trophectoderm. UCH-L3 present in the inner cells | Mus musculus | - |
embryo | UCH-L1 and UCH-L3 present during all of the embryonic stages. UCH-L1 is essentially constant in all cases, but the level of UCH-L3 is lower in the blastocyst stage. Developing embryos of gad and Uchl3 knockout mice are negative for UCH-L1 and UCH-L3 | Mus musculus | - |
oocyte | UCH-L1 and UCH-L3 present in mature oocytes. Oocytes of gad and Uchl3 knockout mice ovaries are negative for UCH-L1 and UCH-L3, respectively | Mus musculus | - |
ovary | UCH-L1 and UCH-L3 are expressed in ovaries during proestrus, estrus, metestrus, and diestrus. Both proteins are present at all estrous cycle stages in wild-type mice. UCH-L1 is absent from gad ovaries and UCH-L3 from Uchl3 knockout ovaries | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin carboxyl-terminal hydrolase L1 | - |
Mus musculus |
UCH-L1 | - |
Mus musculus |
UCH-L3 | - |
Mus musculus |