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Literature summary for 3.4.19.12 extracted from

  • Takami, Y.; Nakagami, H.; Morishita, R.; Katsuya, T.; Cui, T.X.; Ichikawa, T.; Saito, Y.; Hayashi, H.; Kikuchi, Y.; Nishikawa, T.; Baba, Y.; Yasuda, O.; Rakugi, H.; Ogihara, T.; Kaneda, Y.
    Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation (2007), Arterioscler. Thromb. Vasc. Biol., 27, 2184-2190.
    View publication on PubMed
Search for more literature for 3.4.19.12

Activating Compound

Activating Compound Comment Organism Structure
additional information treatment of aortic endothelial cells and aortic smooth muscle cells with human recombinant epidermal growth factor, fibroblast growth factor-2, vascular endothelial growth factor, lipopolysaccharide, angiotensin II or hydrogen peroxide for 24 hours does not significantly alter UCHL1 mRNA levels Homo sapiens
tumor necrosis factor-alpha treatment of cultured vascular smooth muscle cells for 24 and 48 hours does not significantly alter UCHL1 mRNA levels, whereas long term treatment (96 hours) significantly increases UCHL1 mRNA levels. Treatment of aortic endothelial cells and aortic smooth muscle cells with tumor necrosis factor-alpha for 24 hours does not significantly alter UCHL1 mRNA levels Homo sapiens

Application

Application Comment Organism
medicine overexpression of UCHL1 significantly attenuates tumor necrosis factor-alpha–induced nuclear factor-kappa B activity in vascular cells and increases inhibitor of kappa B-alpha, possibly through the attenuation of kappa B-alpha ubiquitination, leading to decreased neointima in the balloon-injured artery Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in BAEC cells Homo sapiens
human UCHL1 and bovine eNOS subcloned into D-TOPO and transferred into the mammalian expression vector pcDNA3.1 or pCAGGS, transfection of plasmid DNA in rat carotid artery Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
siRNA knockdown of UCHL1 by small interfering RNA results in increased nuclear factor-kappa B activity in A7r5 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aortic endothelial cell mRNA and protein expression, expressed in endothelial cells in atherosclerotic lesions from human carotid arteries Homo sapiens
-
aortic smooth muscle mRNA and protein expression Homo sapiens
-
brain
-
 Homo sapiens
-
additional information vasculature Homo sapiens
-
vascular smooth muscle cell mRNA and protein expression, expressed in vascular smooth muscle cells in atherosclerotic lesions from human carotid arteries Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inhibitor of kappa B-alpha + H2O UCHL1 deubiquitinates, thereby resulting in nuclear factor-kappa B inactivation Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ubiquitin carboxyl-terminal hydrolase L1
-
 Homo sapiens
UCHL1
-
 Homo sapiens