Application | Comment | Organism |
---|---|---|
medicine | transient ischemia induces selective delayed motor neuronal death and affects the profile of expression of ubiquitin, parkin, and UCH-L1. Vulnerability of motor neuron of the spinal cord may be partially attributed to the different response in ubiquitin-mediated stress response after transient ischemia | Oryctolagus cuniculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | UCH-L1 is slightly expressed both in interneuron and motor neuron. After 3 hours ischemia, UCH-L1 is upregulated in cytoplasm of both neurons. After 6 hours, UCH-L1 in cytoplasm is preserved in motor neuron, whereas it returns to almost the same level as the sham group in interneuron | Oryctolagus cuniculus | 5737 | - |
additional information | UCH-L1 is not detectable in nuclei of interneuron and motor neuron. UCH-L1 is upregulated strongly at 3 hours and somewhat decreased at 6 hours of ischemia, is well preserved until 1 day, whereas it is not detectable in nuclei of motor neuron after ischemia | Oryctolagus cuniculus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25000 | - |
Western blot analysis | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | interneuron and motor neuron | Oryctolagus cuniculus | - |
spinal cord | - |
Oryctolagus cuniculus | - |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin carboxy-terminal hydrolase 1 | - |
Oryctolagus cuniculus |
UCH-L1 | - |
Oryctolagus cuniculus |