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Literature summary for 3.4.19.12 extracted from
- Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors (2008), Hepatology, 48, 508-518.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| into the pcDNA3.1-TOPO vector and expressed in HCT-116 or EC-109 cells | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | epigenetic inactivation of UCHL1 is common in primary hepatocellular carcinomas and other digestive tumors. UCHL1 appears to be a functional tumor suppressor involved in the tumorigenesis of hepatocellular carcinomas and other digestive cancers. Ectopic expression of UCHL1 induces apoptosis through intrinsic caspase-dependent pathway. UCHL1 directly interacts with p53 and inhibits p53 protein degradation | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P09936 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone marrow | - |
Homo sapiens | - |
| brain | - |
Homo sapiens | - |
| breast | - |
Homo sapiens | - |
| colon | - |
Homo sapiens | - |
| esophagus | - |
Homo sapiens | - |
| heart | - |
Homo sapiens | - |
| Hep-G2 cell | UCHL1 expression is low, which is well correlated with its promoter methylation status | Homo sapiens | - |
| Huh-7 cell | UCHL1 expression is low, which is well correlated with its promoter methylation status | Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| larynx | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| lymph node | - |
Homo sapiens | - |
| additional information | present in HuH-4 cells. Cancer cell lines HCT-116, EC-109, Hep-3B, HuH-1, HuH-6, Mahlavu, SNU-387 and SNU-449 have silenced UCHL1, which is well correlated with its promoter methylation status | Homo sapiens | - |
| ovary | - |
Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
| placenta | - |
Homo sapiens | - |
| PLC-PRF-5 cell | UCHL1 expression is low, which is well correlated with its promoter methylation status | Homo sapiens | - |
| prostate | - |
Homo sapiens | - |
| rectum | - |
Homo sapiens | - |
| skeletal muscle | - |
Homo sapiens | - |
| SNU-398 cell | - |
Homo sapiens | - |
| SNU-423 cell | UCHL1 expression is low, which is well correlated with its promoter methylation status | Homo sapiens | - |
| SNU-475 cell | - |
Homo sapiens | - |
| spleen | - |
Homo sapiens | - |
| stomach | - |
Homo sapiens | - |
| testis | - |
Homo sapiens | - |
| trachea | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | epigenetic inactivation of UCHL1 is common in primary hepatocellular carcinomas and other digestive tumors. UCHL1 appears to be a functional tumor suppressor involved in the tumorigenesis of hepatocellular carcinomas and other digestive cancers. Ectopic expression of UCHL1 induces apoptosis through intrinsic caspase-dependent pathway. UCHL1 directly interacts with p53 and inhibits p53 protein degradation | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ubiquitin carboxyl-terminal hydrolase L1 | - |
Homo sapiens |
| UCHL1 | - |
Homo sapiens |
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