Literature summary for 3.4.19.12 extracted from

Wang, W.J.; Li, Q.Q.; Xu, J.D.; Cao, X.X.; Li, H.X.; Tang, F.; Chen, Q.; Yang, J.M.; Xu, Z.D.; Liu, X.P.
Over-expression of ubiquitin carboxy terminal hydrolase-L1 induces apoptosis in breast cancer cells (2008), Int. J. Oncol., 33, 1037-1045.

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Cloned(Commentary)

Cloned (Comment)	Organism
pcDNA3.1-UCH-L1 plasmid overexpressed in MCF7 and MCF7/Adr cells	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	silencing of UCH-L1 in MCF7/Adr cells does not suppress cell growth. Overexpression of UCH-L1 in MCF7 cells induces apoptosis. Apoptosis triggered by UCH-L1 is, at least in part, probably through phosphoinositide 3-kinase/Akt signal pathway	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09936	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	silencing of UCH-L1 in MCF7/Adr cells does not suppress cell growth. Overexpression of UCH-L1 in MCF7 cells induces apoptosis. Apoptosis triggered by UCH-L1 is, at least in part, probably through phosphoinositide 3-kinase/Akt signal pathway	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
ubiquitin carboxy terminal hydrolase-L1	-	Homo sapiens
UCH-L1	-	Homo sapiens

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Release 2023.1 (January 2023)