Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | UCH-L1 activity is regulated by synaptic activity. Stimulation of synaptic activity by NMDA/glycine significantly up-regulates UCH-L1 activity in cultured neurons. NMDA-induced up-regulation of UCH-L1 activity is efficiently blocked by pre-treatment of neurons with the NMDA receptor antagonist D-2-amino-5-phosphonopentanoic acid | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LDN-57444 | i.e. 3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
dendrite | - |
Rattus norvegicus | 30425 | - |
additional information | UCHL1 expression is detected in both soma and dendrites of hippocampal neurons. UCH-L1 is distributed in a micropunctate fashion, localized to dendritic spines of neurons, and partially co-localized with PSD-95, overview | Rattus norvegicus | - |
- |
soluble | - |
Rattus norvegicus | - |
- |
synapse | - |
Rattus norvegicus | 45202 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | UCHL1 can act as a ubiquitin hydrolase, and generate free ubiquitin species from precursor ubiquitin polypeptides. Synaptic activation of UCH-L1 is correlated with an increase in the levels of free monomeric ubiquitin | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | specific expression of UCH-L1 | Rattus norvegicus | - |
hippocampus | - |
Rattus norvegicus | - |
neuron | primary hippocampal neuronal culture | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | UCHL1 can act as a ubiquitin hydrolase, and generate free ubiquitin species from precursor ubiquitin polypeptides. Synaptic activation of UCH-L1 is correlated with an increase in the levels of free monomeric ubiquitin | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | UCH-L1 belongs to a family of de-ubiquitinating enzymes, comprising of UCH-L1-5 | Rattus norvegicus |
ubiquitin C-terminal hydrolase L1 | - |
Rattus norvegicus |
UCH-L1 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | altered UCH-L1 activity leads to deleterious effects on synapse structure and function. Inhibition of UCH-L1 activity affects synaptic protein clusters | Rattus norvegicus |
physiological function | UCH-L1 is one of the major de-ubiquitinating enzymes in the brain which controls ubiquitin homeostasis. UCH-L1 function is required for synaptic plasticity and is itself regulated by synaptic activity. UCH-L1 activity is required for NMDA-induced up-regulation of free monomeric ubiquitin. UCH-L1 can also bind to ubiquitin and act as a ubiquitin stabilizer to prevent its degradation by lysosomes. UCH-L1 regulates spine morphology and density | Rattus norvegicus |