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Literature summary for 3.4.19.6 extracted from

  • Bauer, K.; Nowak, P.
    Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond (1979), Eur. J. Biochem., 99, 239-246.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Cd2+
-
Sus scrofa
Chelating agents
-
Sus scrofa
CuSO4
-
Sus scrofa
DTT
-
Sus scrofa
EDTA
-
Sus scrofa
Hg2+
-
Sus scrofa
metal chelators
-
Sus scrofa
additional information no inhibition by NEM; no inhibition by serine protease inhibitors; no inhition by 2-iodoacetamide Sus scrofa
Ni2+
-
Sus scrofa
PCMB
-
Sus scrofa
ZnSO4
-
Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
260000
-
gel filtration Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thyroliberin + H2O cleavage at the pyroglutamyl-histidine bond Sus scrofa pyroglutamic acid + His-Pro-NH2
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
40
-
-
Sus scrofa

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
25 55 about 70% of activity maximum at 25°C and 55°C Sus scrofa

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
rapid and irreversible inactivation above Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 8
-
Sus scrofa

pH Range

pH Minimum pH Maximum Comment Organism
5.7 8.5 pH 5.7: about 35% of maximal activity, pH 8.5: about 45% of maximal activity Sus scrofa