Any feedback?
Literature summary for 3.4.19.9 extracted from
- gamma-Glutamyl hydrolase, not glutamate carboxypeptidase II, hydrolyzes dietary folate in rat small intestine (2007), J. Nutr., 137, 1149-1153.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-hydroxymercuribenzoate | - |
Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| brush border membrane | - |
Rattus norvegicus | 31526 | - |
| extracellular | - |
Rattus norvegicus | - |
- |
| intracellular | - |
Rattus norvegicus | 5622 | - |
| lysosome | - |
Rattus norvegicus | 5764 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| polyglutamyl-folate + H2O | Rattus norvegicus | gamma-glutamyl hydrolase, not glutamate carboxypeptidase II, hydrolyzes dietary folate in rat small intestine | monoglutamyl folate + glutamate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Sprague-Dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bile | - |
Rattus norvegicus | - |
| duodenal luminal fluid | high activity at pH 4.5 | Rattus norvegicus | - |
| duodenum | - |
Rattus norvegicus | - |
| enterocyte | - |
Rattus norvegicus | - |
| hepatocyte | - |
Rattus norvegicus | - |
| ileum | - |
Rattus norvegicus | - |
| jejunum | enzyme expression in mucosa | Rattus norvegicus | - |
| liver | enzyme expression | Rattus norvegicus | - |
| mucosa | duodenal, jejunal, and ileal mucosa | Rattus norvegicus | - |
| pancreas | enzyme expression | Rattus norvegicus | - |
| pancreatic juice | - |
Rattus norvegicus | - |
| serum | - |
Rattus norvegicus | - |
| small intestine | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
highest activity in the postprandial duodenal luminal fluid at pH 4.5 | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| polyglutamyl-folate + H2O | - |
Rattus norvegicus | monoglutamyl folate + glutamate | - |
? | |
| polyglutamyl-folate + H2O | gamma-glutamyl hydrolase, not glutamate carboxypeptidase II, hydrolyzes dietary folate in rat small intestine | Rattus norvegicus | monoglutamyl folate + glutamate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| folate hydrolase | - |
Rattus norvegicus |
| gamma-GH | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | 6.5 | 4.5 is the pH optimum, while pH 6.5 is the in vivo reaction temperature | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
