Inhibitors | Comment | Organism | Structure |
---|---|---|---|
actinomycin | no remaining enzyme activityafter 20 h | Mus musculus | |
cycloheximide | 61% inhibition at 0.01 mg/ml after 3 h, complete inhibition after 20 h | Mus musculus | |
EDTA | complete inhibition at 10 mM | Mus musculus | |
Triton X-100 | complete inactivation at 0.05% | Mus musculus | |
vitamin K | induction of enzyme activity | Mus musculus | |
warfarin | 62% inhibition at 0.02 mg/ml after 3 h, and 90% after 20 h | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | secretion to the medium | Mus musculus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
x * 45000, SDS-PAGE | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | Mus musculus | - |
thrombin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin | scutelarin has similar specificity | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | peritoneal | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | - |
Mus musculus | thrombin + ? | - |
? | |
S2222 + H2O | chromogenic synthetic peptide substrate | Mus musculus | ? | - |
? | |
S2238 + H2O | chromogenic synthetic peptide substrate | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 45000, SDS-PAGE | Mus musculus |
More | factor Xa is part of the prothrombinase complex | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme belongs to the peptidase family S1, i.e. trypsin family | Mus musculus |
prothrombinase | - |
Mus musculus |