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Literature summary for 3.4.22.1 extracted from

  • Simon, J.; Duffy, M.J.
    Characterization of a cathepsin B-like enzyme from breast cancer (1986), Biochem. Soc. Trans., 14, 460.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
2-mercaptoethanol activates Homo sapiens
cysteine activates Homo sapiens
dithiothreitol activates Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
iodoacetic acid
-
Homo sapiens
L-3-carboxy-2,3-trans-epoxypropionyl-leucylamido-(4-guanidino)butane E-64 Homo sapiens
leupeptin
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.012
-
benzyloxycarbonyl-Val-Lys-Lys-Arg-4-methoxy-beta-naphthylamide
-
Homo sapiens
0.022
-
benzyloxycarbonyl-Ala-Arg-Arg-4-methoxy-beta-naphthylamide
-
Homo sapiens
0.038
-
benzyloxycarbonyl-Arg-Arg-4-methylcoumaryl-7-amide
-
Homo sapiens
0.038
-
benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl-7-amide
-
Homo sapiens
0.05
-
Arg-4-methylcoumaryl-7-amide
-
Homo sapiens
0.055
-
benzyloxycarbonyl-Arg-Arg-4-methoxy-beta-naphthylamide
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Proteins + H2O Homo sapiens plays a role in cancer invasion and metastasis ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Arg-4-methylcoumaryl-7-amide + H2O
-
Homo sapiens Arg + 7-amino-4-methylcoumarin
-
?
benzyloxycarbonyl-Ala-Arg-Arg-4-methoxy-beta-naphthylamide + H2O
-
Homo sapiens benzyloxycarbonyl-Ala-Arg-Arg + 4-methoxy-beta-naphthylamine
-
?
benzyloxycarbonyl-Arg-Arg-4-methoxy-beta-naphthylamide + H2O
-
Homo sapiens benzyloxycarbonyl-Arg-Arg + 4-methoxy-beta-naphthylamine
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
-
Homo sapiens benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
?
benzyloxycarbonyl-Arg-Arg-beta-naphthylamide + H2O
-
Homo sapiens benzyloxycarbonyl-Arg-Arg + beta-naphthylamine
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
-
Homo sapiens benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
?
benzyloxycarbonyl-Val-Lys-Lys-Arg-4-methoxy-beta-naphthylamide + H2O
-
Homo sapiens ? + 4-methoxy-beta-naphthylamine
-
?
Collagen + H2O
-
Homo sapiens Hydrolyzed collagen
-
?
Proteins + H2O plays a role in cancer invasion and metastasis Homo sapiens ?
-
?
proteoglycans + H2O
-
Homo sapiens hydrolyzed proteoglycans
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.004
-
Arg-4-methylcoumaryl-7-amide
-
Homo sapiens
0.125
-
benzyloxycarbonyl-Ala-Arg-Arg-4-methoxy-beta-naphthylamide
-
Homo sapiens
0.139
-
benzyloxycarbonyl-Arg-Arg-4-methoxy-beta-naphthylamide
-
Homo sapiens
0.149
-
benzyloxycarbonyl-Arg-Arg-4-methylcoumaryl-7-amide
-
Homo sapiens
0.325
-
benzyloxycarbonyl-Val-Lys-Lys-Arg-4-methoxy-beta-naphthylamide
-
Homo sapiens
0.445
-
benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl-7-amide
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
-
Homo sapiens