Any feedback?
Literature summary for 3.4.22.1 extracted from
- Purification and characterization of cathepsin B from monkey skeletal muscle (1984), J. Biochem., 95, 871-879.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 2-mercaptoethanol | activates | Macaca fuscata |  |
| cysteine | activates | Macaca fuscata | |
| dithiothreitol | activates | Macaca fuscata | |
| thiol compounds | required for full activity | Macaca fuscata | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| antipain | - |
Macaca fuscata | |
| chymostatin | - |
Macaca fuscata | |
| iodoacetic acid | - |
Macaca fuscata | |
| L-3-carboxy-2,3-trans-epoxypropionyl-leucylamido-(4-guanidino)butane | E-64 | Macaca fuscata | |
| leupeptin | - |
Macaca fuscata | |
| N-tosyl-lysyl chloromethylketone | - |
Macaca fuscata | |
| N-tosyl-phenylalanine chloromethylketone | - |
Macaca fuscata | |
| p-chloromercuribenzoate | - |
Macaca fuscata | |
| p-chloromercuriphenyl sulfonic acid | - |
Macaca fuscata | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 24000 | - |
gel filtration | Macaca fuscata |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Proteins + H2O | Macaca fuscata | muscle proteins | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Macaca fuscata | - |
monkey | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Macaca fuscata |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| muscle | - |
Macaca fuscata | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| azocasein + H2O | poor substrate | Macaca fuscata | fragments of azocasein | - |
? | |
| benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide | - |
Macaca fuscata | benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin | - |
? | |
| myosin + H2O | - |
Macaca fuscata | hydrolyzed myosin | - |
? | |
| neuropeptides + H2O | such as Leu-enkephalin, beta-neoendorphin, alpha-neoendorphin, dynorphin(1-13), substance P | Macaca fuscata | hydrolyzed neuropeptides | - |
? | |
| Proteins + H2O | muscle proteins | Macaca fuscata | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 5 | myosin as substrate | Macaca fuscata |
| 6.5 | - |
benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl-7-amide as substrate | Macaca fuscata |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 7 | activity decreases sharply above pH 7.0 | Macaca fuscata |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
