Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.15 extracted from

  • Kirschke, H.; Langner, J.; Wiederanders, B.; Ansorge, S.; Bohley, P.
    Cathepsin L. A new proteinase from rat-liver lysosomes (1977), Eur. J. Biochem., 74, 293-301.
    View publication on PubMed
Search for more literature for 3.4.22.15

Activating Compound

Activating Compound Comment Organism Structure
ATP activates Rattus norvegicus
CoA activates Rattus norvegicus
EDTA activates Rattus norvegicus
Soybean trypsin inhibitor activates Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis(2-nitrobenzoic acid)
-
 Rattus norvegicus
Azodicarboxylic acid alpha-morpholide
-
 Rattus norvegicus
diazinedicarboxylic acid bisdimethylamide
-
 Rattus norvegicus
Hg2+
-
 Rattus norvegicus
iodoacetamide
-
 Rattus norvegicus
iodoacetic acid
-
 Rattus norvegicus
Leu-CH2Cl
-
 Rattus norvegicus
leupeptin pseudo-irreversible inhibitor Rattus norvegicus
methylphenylazoformate
-
 Rattus norvegicus
Mn2+
-
 Rattus norvegicus
NEM
-
 Rattus norvegicus
PCMB
-
 Rattus norvegicus
tosyl-Lys-CH2Cl
-
 Rattus norvegicus
tosyl-Phe-CH2Cl
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Rattus norvegicus 5764
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0517
-
-
 Rattus norvegicus

Storage Stability

Storage Stability Organism
4°C, remarkable loss of activity Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
azocasein + H2O
-
 Rattus norvegicus ?
-
 ?
benzoyl-Arg-4-nitroanilide + H2O
-
 Rattus norvegicus benzoyl-Arg + 4-nitroaniline
-
 ?
Collagen + H2O
-
 Rattus norvegicus ?
-
 ?
Glucagon + H2O
-
 Rattus norvegicus ?
-
 ?
Hemoglobin + H2O
-
 Rattus norvegicus ?
-
 ?
histone + H2O
-
 Rattus norvegicus ?
-
 ?
insulin + H2O
-
 Rattus norvegicus ?
-
 ?
N2-benzoyl-L-argininamide + H2O
-
 Rattus norvegicus NH3 + N2-benzoyl-L-arginine
-
 ?
Nalpha-benzoyl-L-Arg 2-naphthylamide + H2O
-
 Rattus norvegicus Nalpha-benzoyl-L-Arg + 2-naphthylamine
-
 ?

Subunits

Subunits Comment Organism
? x * 23000-24000, SDS-PAGE Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
 hydrolysis of azocasein, glucagon or benzoyl-Arg-NH2 Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
3 7 pH 3.0: 40-50% of maximal activity, pH 7.0: 20-30% of maximal activity Rattus norvegicus