Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Oryctolagus cuniculus | |
Ca2+ | required, 7 mM | Homo sapiens | |
Cd2+ | - |
Oryctolagus cuniculus | |
Cd2+ | required, 1 mM | Homo sapiens | |
Mg2+ | - |
Oryctolagus cuniculus | |
Mg2+ | required, 7 mM | Homo sapiens | |
Mn2+ | - |
Oryctolagus cuniculus | |
Mn2+ | required, 0.1 mM | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
antipain | - |
Homo sapiens | |
antipain | - |
Oryctolagus cuniculus | |
Cu2+ | inactivation | Homo sapiens | |
Cu2+ | inactivation | Oryctolagus cuniculus | |
Fe2+ | inactivation | Homo sapiens | |
Fe2+ | inactivation | Oryctolagus cuniculus | |
iodoacetamide | - |
Homo sapiens | |
iodoacetamide | - |
Oryctolagus cuniculus | |
leupeptin | - |
Homo sapiens | |
leupeptin | - |
Oryctolagus cuniculus | |
Mercuric chloride | - |
Homo sapiens | |
Mercuric chloride | - |
Oryctolagus cuniculus | |
additional information | no inhibition by alpha2-macroglobulin, alpha1-antiprotease, antithrombin III/heparin, cystatin, cysteamine, alpha1-anichymotrypsin, the effectiveness of most of the inhibitors increase in presence of reducing agents | Homo sapiens | |
p-chloromercuric benzoate | - |
Homo sapiens | |
Peptidyl diazomethyl ketones | - |
Homo sapiens | |
Peptidyl diazomethyl ketones | - |
Oryctolagus cuniculus | |
PMSF | - |
Homo sapiens | |
PMSF | - |
Oryctolagus cuniculus | |
Sn2+ | inactivation | Homo sapiens | |
Sn2+ | inactivation | Oryctolagus cuniculus | |
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane | i.e. E-64, reversible, competitive | Homo sapiens | |
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane | ie.e. E-64, reversible, competitive | Oryctolagus cuniculus | |
Zn2+ | inactivation | Homo sapiens | |
Zn2+ | inactivation | Oryctolagus cuniculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | divalent metal ions are responsible for correct conformation of the enzyme, enzyme contains 2 metal binding sites: 1 for Ca2+ and Mg2+ binding, and 1 for Mn2+ and Cd2+ binding | Homo sapiens | |
additional information | divalent metal ions are responsible for correct conformation of the enzyme, enzyme contains 2 metal binding sites: 1 for Ca2+ and Mg2+ binding, and 1 for Mn2+ and Cd2+ binding | Oryctolagus cuniculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
68000 | - |
- |
Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor X + H2O | Homo sapiens | cleavage of Arg-Ile bond in factor X heavy chain, activation of the coaglutation factor X and thereby activation of the plasma blood clotting cascade | factor Xa | - |
? | |
factor X + H2O | Oryctolagus cuniculus | cleavage of Arg-Ile bond in factor X heavy chain, activation of the coaglutation factor X and thereby activation of the plasma blood clotting cascade | factor Xa | - |
? | |
additional information | Homo sapiens | enzyme seems to be regulated allosterically | ? | - |
? | |
PAR-1 receptor + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
no glycoprotein | - |
Homo sapiens |
no glycoprotein | - |
Oryctolagus cuniculus |
Purification (Comment) | Organism |
---|---|
- |
Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amnion | - |
Homo sapiens | - |
carcinoma cell | V2 carcinoma cell | Oryctolagus cuniculus | - |
chorion | - |
Homo sapiens | - |
leukemia cell | - |
Homo sapiens | - |
additional information | produced by malignant and fetal cells | Homo sapiens | - |
additional information | produced by malignant and fetal cells | Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-Ala-Pro-Arg-4-nitroanilide + H2O | - |
Homo sapiens | D-Ala-Pro-Arg + 4-nitroaniline | - |
? | |
D-Ile-Pro-Arg-4-nitroanilide + H2O | - |
Homo sapiens | D-Ile-Pro-Arg + 4-nitroaniline | - |
? | |
factor X + H2O | cleavage of Arg-Ile bond | Oryctolagus cuniculus | factor Xa | - |
? | |
factor X + H2O | cleavage of Arg-Ile bond in factor X heavy chain | Homo sapiens | factor Xa | - |
? | |
factor X + H2O | cleavage of Arg-Ile bond in factor X heavy chain, activation of the coaglutation factor X and thereby activation of the plasma blood clotting cascade | Homo sapiens | factor Xa | - |
? | |
factor X + H2O | cleavage of Arg-Ile bond in factor X heavy chain, activation of the coaglutation factor X and thereby activation of the plasma blood clotting cascade | Oryctolagus cuniculus | factor Xa | - |
? | |
Glu-Glu-Pro-Arg-4-nitroanilide + H2O | - |
Homo sapiens | Glu-Glu-Pro-Arg + 4-nitroaniline | - |
? | |
additional information | substrate recognition depends on the secondary and tertiary configuration of the protein substrate rather than on the primary sequence alone, no activity with substrates containing the sequence Xaa-Lys-ProP2-TyrP1- | Homo sapiens | ? | - |
? | |
additional information | enzyme seems to be regulated allosterically | Homo sapiens | ? | - |
? | |
N-p-tosyl-Gly-Pro-Arg-4-nitroanilide + H2O | - |
Homo sapiens | N-p-tosyl-Gly-Pro-Arg + 4-nitroaniline | - |
? | |
N-p-tosyl-Gly-Pro-Lys-4-nitroanilide + H2O | - |
Homo sapiens | N-p-tosyl-Gly-Pro-Lys + 4-nitroaniline | - |
? | |
PAR-1 receptor + H2O | - |
Homo sapiens | ? | - |
? | |
PAR-1 receptor + H2O | enzyme competes with thrombin for the same protease-activated receptor, i.e. PAR-1, on the blood platelet surface | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 68000 | Oryctolagus cuniculus |
Synonyms | Comment | Organism |
---|---|---|
cancer procoagulant | - |
Homo sapiens |
cancer procoagulant | - |
Oryctolagus cuniculus |
CP | - |
Homo sapiens |
CP | - |
Oryctolagus cuniculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.128 | - |
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane | - |
Homo sapiens |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
4.8 |