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Literature summary for 3.4.22.36 extracted from

  • Lamkanfi, M.; Kanneganti, T.D.; Van Damme, P.; Vanden Berghe, T.; Vanoverberghe, I.; Vandekerckhove, J.; Vandenabeele, P.; Gevaert, K.; Nunez, G.
    Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes (2008), Mol. Cell. Proteomics, 7, 2350-2363.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.36

Activating Compound

Activating Compound Comment Organism Structure
additional information Salmonella- and lipopolysaccharide-, and ATP-induced activation of caspase-7 by caspase-1. Caspase-1 activation involves pattern recognition receptors Ipaf and Cryopyrin, and the inflammasome adaptor ASC Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information Salmonella- and lipopolysaccharide-, and ATP-induced activation of caspase-7 is abolished in macrophages deficient in caspase-1, the pattern recognition receptors Ipaf and Cryopyrin, and the inflammasome adaptor ASC Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
Ac-YVAD-chloromethyl ketone
-
 Mus musculus
iodoacetamide
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus caspase-1 is activated by the inflammasomes and is responsible for the proteolytic maturation of the cytokines interleukin-1beta and interleukin-18 during infection and inflammation ?
-
 ?
additional information Mus musculus C57BL/6 caspase-1 is activated by the inflammasomes and is responsible for the proteolytic maturation of the cytokines interleukin-1beta and interleukin-18 during infection and inflammation ?
-
 ?
pro-caspase-7 + H2O Mus musculus caspase-1-mediates activation of endogenous caspase-7 caspase-7 + ?
-
 ?
pro-caspase-7 + H2O Mus musculus C57BL/6 caspase-1-mediates activation of endogenous caspase-7 caspase-7 + ?
-
 ?
pro-interleukin-18 + H2O Mus musculus
-
 interleukin-18 + ?
-
 ?
pro-interleukin-1beta + H2O Mus musculus
-
 interleukin-1beta + ?
-
 ?
pro-interleukin-1beta + H2O Mus musculus C57BL/6
-
 interleukin-1beta + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Assc2 peptide + H2O
-
 Mus musculus ?
-
 ?
beta-actin + H2O
-
 Mus musculus ?
-
 ?
beta-actin + H2O
-
 Mus musculus C57BL/6 ?
-
 ?
cPLA2 peptide + H2O
-
 Mus musculus ?
-
 ?
cyclin G-associated kinase + H2O
-
 Mus musculus ?
-
 ?
elF-4H peptide + H2O
-
 Mus musculus ?
-
 ?
endoplasmin + H2O
-
 Mus musculus ?
-
 ?
FLP-1 peptide + H2O
-
 Mus musculus ?
-
 ?
FYN-binding protein + H2O
-
 Mus musculus ?
-
 ?
gamma-actin + H2O
-
 Mus musculus ?
-
 ?
GIT2 peptide + H2O
-
 Mus musculus ?
-
 ?
heat shock protein 60 + H2O
-
 Mus musculus ?
-
 ?
histone E3 peptide + H2O
-
 Mus musculus ?
-
 ?
ligatin + H2O
-
 Mus musculus ?
-
 ?
MCM3 peptide + H2O
-
 Mus musculus ?
-
 ?
additional information caspase-1 is activated by the inflammasomes and is responsible for the proteolytic maturation of the cytokines interleukin-1beta and interleukin-18 during infection and inflammation Mus musculus ?
-
 ?
additional information peptide substrate screening, the enzyme preferably cleaves after Asp, overview Mus musculus ?
-
 ?
additional information caspase-1 is activated by the inflammasomes and is responsible for the proteolytic maturation of the cytokines interleukin-1beta and interleukin-18 during infection and inflammation Mus musculus C57BL/6 ?
-
 ?
additional information peptide substrate screening, the enzyme preferably cleaves after Asp, overview Mus musculus C57BL/6 ?
-
 ?
periphilin-1 + H2O
-
 Mus musculus ?
-
 ?
PREL-1 peptide + H2O
-
 Mus musculus ?
-
 ?
pro-caspase-7 + H2O caspase-1-mediates activation of endogenous caspase-7 Mus musculus caspase-7 + ?
-
 ?
pro-caspase-7 + H2O caspase-1-mediates activation of endogenous caspase-7 Mus musculus C57BL/6 caspase-7 + ?
-
 ?
pro-caspase-7 + H2O consensus caspase-7 recognition sequence DEVD, caspase-1 cleaves caspase-7 at the canonical activation sites Asp23 and Asp198, D23A/D198A double caspase-7 mutant is no substrate Mus musculus caspase-7 + amino-terminal procaspase-7 peptide
-
 ?
pro-interleukin-18 + H2O
-
 Mus musculus interleukin-18 + ?
-
 ?
pro-interleukin-1beta + H2O
-
 Mus musculus interleukin-1beta + ?
-
 ?
pro-interleukin-1beta + H2O
-
 Mus musculus C57BL/6 interleukin-1beta + ?
-
 ?
SMG7 peptide + H2O
-
 Mus musculus ?
-
 ?
target of Myb protein 1 pepitde + H2O
-
 Mus musculus ?
-
 ?
TIF1b peptide + H2O
-
 Mus musculus ?
-
 ?
Vsp72 peptide + H2O
-
 Mus musculus ?
-
 ?