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Literature summary for 3.4.22.69 extracted from
- Synthesis and evaluation of benzoquinolinone derivatives as SARS-CoV 3CL protease inhibitors (2010), Bull. Korean Chem. Soc., 31, 87-91.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-[1-(4-benzyloxyphenyl)-1H-tetrazol-5-ylthio]-4-hydroxyquinolin-2-(1H)one | - |
Severe acute respiratory syndrome-related coronavirus |  |
| 3-[1-(4-benzyloxyphenyl)-1H-tetrazol-5-ylthio]-4-methoxyquinolin-2-(1H)one | - |
Severe acute respiratory syndrome-related coronavirus | |
| 3-[1-(4-ethoxyphenyl)-1H-tetrazol-5-ylthio]-4-hydroxyquinolin-2-(1H)one | - |
Severe acute respiratory syndrome-related coronavirus | |
| 4-benzyloxy-3-[1-(4-benzyloxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one | - |
Severe acute respiratory syndrome-related coronavirus | |
| 4-benzyloxy-3-[1-(4-ethoxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one | - |
Severe acute respiratory syndrome-related coronavirus | |
| 4-benzyloxy-3-[1-(4-methoxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one | - |
Severe acute respiratory syndrome-related coronavirus | |
| 4-hydroxy-3-[1-(4-hydroxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one | - |
Severe acute respiratory syndrome-related coronavirus | |
| 4-hydroxy-3-[1-(4-methoxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one | - |
Severe acute respiratory syndrome-related coronavirus | |
| 5,7-dichloro-4-hydroxy-3-[1-(4-methoxy-phenyl)-1H-tetrazol-5-ylsulfanyl]-1H-quinolin-2-one | - |
Severe acute respiratory syndrome-related coronavirus | |
| 5,7-dichloro-4-hydroxy-3-[[1-(4-hydroxyphenyl)-1H-tetrazol-5-yl]sulfanyl]quinolin-2(1H)-one | - |
Severe acute respiratory syndrome-related coronavirus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Severe acute respiratory syndrome-related coronavirus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Severe acute respiratory syndrome-related coronavirus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Dabcyl-KTSAVLQSGFRKME-EDANS + H2O | - |
Severe acute respiratory syndrome-related coronavirus | Dabcyl-KTSAVLQ + SGFRKME-EDANS | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3C-like protease | - |
Severe acute respiratory syndrome-related coronavirus |
| 3CL protease | - |
Severe acute respiratory syndrome-related coronavirus |
| 3cLpro | - |
Severe acute respiratory syndrome-related coronavirus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.002 | - |
in 10 mM HEPES at pH 7.5, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 3-[1-(4-benzyloxyphenyl)-1H-tetrazol-5-ylthio]-4-methoxyquinolin-2-(1H)one | |
| 0.01 | - |
in 10 mM HEPES at pH 7.5, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 5,7-dichloro-4-hydroxy-3-[[1-(4-hydroxyphenyl)-1H-tetrazol-5-yl]sulfanyl]quinolin-2(1H)-one | |
| 0.01 | - |
in 10 mM HEPES at pH 7.5, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 3-[1-(4-benzyloxyphenyl)-1H-tetrazol-5-ylthio]-4-hydroxyquinolin-2-(1H)one | |
| 0.0125 | - |
in 10 mM HEPES at pH 7.5, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 4-benzyloxy-3-[1-(4-ethoxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one | |
| 0.0125 | - |
in 10 mM HEPES at pH 7.5, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 4-benzyloxy-3-[1-(4-methoxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one | |
| 0.0125 | - |
in 10 mM HEPES at pH 7.5, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 4-benzyloxy-3-[1-(4-benzyloxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one | |
| 0.0125 | - |
in 10 mM HEPES at pH 7.5, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 3-[1-(4-ethoxyphenyl)-1H-tetrazol-5-ylthio]-4-hydroxyquinolin-2-(1H)one | |
| 0.0125 | - |
in 10 mM HEPES at pH 7.5, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 4-hydroxy-3-[1-(4-methoxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one | |
| 0.0125 | - |
in 10 mM HEPES at pH 7.5, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 4-hydroxy-3-[1-(4-hydroxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one | |
| 0.0125 | - |
in 10 mM HEPES at pH 7.5, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 5,7-dichloro-4-hydroxy-3-[1-(4-methoxy-phenyl)-1H-tetrazol-5-ylsulfanyl]-1H-quinolin-2-one | |
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