Literature summary for 3.4.22.B14 extracted from

Hu, X.; Tian, J.; Kang, H.; Guo, D.; Liu, J.; Liu, D.; Jiang, Q.; Li, Z.; Qu, J.; Qu, L.
Transmissible gastroenteritis virus papain-like protease 1 antagonizes production of interferon-beta through its deubiquitinase activity (2017), BioMed Res. Int., 2017, 7089091 .

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Protein Variants

Protein Variants	Comment	Organism
C32A	mutant is unable to degrade ubiquitinated protein	Transmissible gastroenteritis virus
D196A	mutant is unable to degrade ubiquitinated protein	Transmissible gastroenteritis virus
H183A	mutant is unable to degrade ubiquitinated protein	Transmissible gastroenteritis virus

Organism

Organism	UniProt	Comment	Textmining
Transmissible gastroenteritis virus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ubiquitinated RIG-I + H2O	substrate is a key fegulator in the IFN signaling pathway	Transmissible gastroenteritis virus	ubiquitin + RIG-I	-	?
ubiquitinated STING + H2O	substrate is a key fegulator in the IFN signaling pathway	Transmissible gastroenteritis virus	ubiquitin + STINGI	-	?

Synonyms

Synonyms	Comment	Organism
PL1	-	Transmissible gastroenteritis virus

General Information

General Information	Comment	Organism
physiological function	PL1 can suppress the IFN-beta expression and inhibit the nuclear translocation of interferon regulatory factor 3.The ability to antagonize IFN-beta production is dependent on the intact catalytic activity of PL1. PL1 exerts deubiquitinase activity which strongly inhibits the retinoic acid-induced gene I- and stimulator of interferon gene-dependent IFN expression	Transmissible gastroenteritis virus

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Release 2023.1 (January 2023)