Literature summary for 3.4.22.B14 extracted from

Li, S.; Wang, C.; Jou, Y.; Yang, T.; Huang, S.; Wan, L.; Lin, Y.; Lin, C.
SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-beta via ROS/p38 MAPK/STAT3 pathway (2016), Sci. Rep., 6, 25754 .

Search for more literature for 3.4.22.B14

Organism

Organism	UniProt	Comment	Textmining
Severe acute respiratory syndrome-related coronavirus	P0C6X7	replicase polyprotein; human, i.e. SARS-CoV	-

Synonyms

Synonyms	Comment	Organism
PLpro	-	Severe acute respiratory syndrome-related coronavirus

General Information

General Information	Comment	Organism
physiological function	protease PLpro dose- and time-dependently up-regulates TGF-beta1 and vimentin in A-549 cellsThe TGF-beta1 promoter region between -175 to -60, the Egr-1 binding site, is responsible for TGF-beta1 promoter activation induced by PLpro. PLpro triggers nuclear translocation of Egr-1. In a mouse model with a direct pulmonary injection, PLpro stimulates macrophage infiltration into lung, up-regulating Egr-1, TSP-1, TGF-beta1 and vimentin expression in lung tissues	Severe acute respiratory syndrome-related coronavirus

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Release 2023.1 (January 2023)