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Literature summary for 3.4.22.B30 extracted from

  • Seremwe, M.; Schnellmann, R.G.; Bollag, W.B.
    Calpain-10 activity underlies angiotensin II-induced aldosterone production in an adrenal glomerulosa cell model (2015), Endocrinology, 156, 2138-2149.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
angiotensin II activates the enzyme in vivo, reduced by pan-calpain inhibitors Homo sapiens

Application

Application Comment Organism
medicine the enzyme is a potential target for the development of drug therapies for the treatment of hypertension Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information siRNA-mediated knockdown of calpain-10 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information pan-calpain inhibitors reduce AngII-induced aldosterone production in 2 adrenal glomerulosa cell models, primary bovine zona glomerulosa and human adrenocortical carcinoma cells Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9HC96
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal glomerulosa cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
calpain-10
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction siRNA-mediated knockdown of calpain-10 inhibits aldosterone production and CYP11B2 expression, whereas adenovirus-mediated overexpression of calpain-10 results in increased AngII-induced aldosterone production Homo sapiens
physiological function calpain-10 activity underlies angiotensin II-induced aldosterone production in an adrenal glomerulosa cell model Homo sapiens