Application | Comment | Organism |
---|---|---|
medicine | vaccination of Shetland mares, either with deubiquitinase DUB-positive or DUB-negative recombinant equine arteritis virus. Upon challenge with the virulent KY84 strain of equine arteritis virus, both vaccine viruses proved to be replication competent in vivo. The DUB-negative virus provides a similar degree of protection against clinical disease as its DUB-positive parental counterpart. A possible improvement due to inactivation of PLP2 DUB activity could not be detected under these experimental conditions | equine arteritis virus |
Protein Variants | Comment | Organism |
---|---|---|
T312A/I313V/I353R | mutant lacks deubiquitinase activity, amino acid numbering based on polyprotein | equine arteritis virus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
equine arteritis virus | P19811 | polyprotein | - |
equine arteritis virus Bucyrus | P19811 | polyprotein | - |