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Literature summary for 3.4.22.B50 extracted from

  • van Kasteren, P.B.; Knaap, R.C.; van den Elzen, P.; Snijder, E.J.; Balasuriya, U.B.; van den Born, E.; Kikkert, M.
    In vivo assessment of equine arteritis virus vaccine improvement by disabling the deubiquitinase activity of papain-like protease 2 (2015), Vet. Microbiol., 178, 132-137 .
    View publication on PubMed

Application

Application Comment Organism
medicine vaccination of Shetland mares, either with deubiquitinase DUB-positive or DUB-negative recombinant equine arteritis virus. Upon challenge with the virulent KY84 strain of equine arteritis virus, both vaccine viruses proved to be replication competent in vivo. The DUB-negative virus provides a similar degree of protection against clinical disease as its DUB-positive parental counterpart. A possible improvement due to inactivation of PLP2 DUB activity could not be detected under these experimental conditions equine arteritis virus

Protein Variants

Protein Variants Comment Organism
T312A/I313V/I353R mutant lacks deubiquitinase activity, amino acid numbering based on polyprotein equine arteritis virus

Organism

Organism UniProt Comment Textmining
equine arteritis virus P19811 polyprotein
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equine arteritis virus Bucyrus P19811 polyprotein
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