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Literature summary for 3.4.23.25 extracted from

  • Li, M.; Phylip, L.H.; Lees, W.E.; Winther, J.R.; Dunn, B.M.; Wlodawer, A.; Kay, J.; Gustchina, A.
    The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix (2000), Nat. Struct. Biol., 7, 113-117.
    View publication on PubMed
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Crystallization (Commentary)

Crystallization (Comment) Organism
bound to inhibitor protein IA3, vapor diffusion, space group P6(2)22, unit cell dimensions a = b = 192.66 A, c = 52.09 A Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
protein IA3 Saccharomyces cerevisiae protein Saccharomyces cerevisiae
protein IA3 mutant 2-34
-
 Saccharomyces cerevisiae
protein IA3 mutant M31-M32
-
 Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
 yeast
-

Purification (Commentary)

Purification (Comment) Organism
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Lys-Pro-Ile-Glu-Phe-(NO2)Phe-Arg-Leu + H2O
-
 Saccharomyces cerevisiae Lys-Pro-Ile-Glu-Phe + (NO2)Phe-Arg-Leu
-
 ?

Synonyms

Synonyms Comment Organism
Aspartic proteinase
-
 Saccharomyces cerevisiae
Proteinase A
-
 Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000009
-
 protein IA3 mutant M31-M32 pH 4.7, 37°C Saccharomyces cerevisiae
0.0000011
-
 protein IA3 pH 4.7, 37°C Saccharomyces cerevisiae
0.000003
-
 protein IA3 mutant 2-34 pH 4.7, 37°C Saccharomyces cerevisiae