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Literature summary for 3.4.24.18 extracted from

  • Becker-Pauly, C.; Rose-John, S.
    Meprin and ADAM metalloproteases two sides of the same coin? (2015), Matrix Metalloproteinase Biology (ed. Sagi I. and Gaffney J.P.), 7j, 115-130 .
No PubMed abstract available
Search for more literature for 3.4.24.18

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Homo sapiens
-
-
additional information meprin alpha contains an additional inserted domain (I-domain), which is proteolytically cleaved by furin within the Golgi Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc-dependent metalloendoprotease Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin II + H2O Homo sapiens
-
 ?
-
 ?
bradykinin + H2O Homo sapiens
-
 ?
-
 ?
Collagen IV + H2O Homo sapiens
-
 ?
-
 ?
Fibronectin + H2O Homo sapiens
-
 ?
-
 ?
gastrin + H2O Homo sapiens
-
 ?
-
 ?
laminin V + H2O Homo sapiens
-
 ?
-
 ?
nidogen 1 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16819
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification meprin alpha contains an additional inserted domain (I-domain), which is proteolytically cleaved by furin within the Golgi. Activation of meprin alpha by proteolytic cleavage through furin. Meprin alpha also contains a conserved sequence motif, which gives rise to enzymatic activation by tryptic serine proteases. Pancreatic trypsin performs this activation in the gut. Outside the intestinal tract, meprin alpha can be efficiently activated by plasmin. In the skin, maturation of meprin alpha is done by KLK5 only, not by other KLK proteases Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin II + H2O
-
 Homo sapiens ?
-
 ?
bradykinin + H2O
-
 Homo sapiens ?
-
 ?
Collagen IV + H2O
-
 Homo sapiens ?
-
 ?
Fibronectin + H2O
-
 Homo sapiens ?
-
 ?
gastrin + H2O
-
 Homo sapiens ?
-
 ?
laminin V + H2O
-
 Homo sapiens ?
-
 ?
nidogen 1 + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More meprin alpha is the largest secreted protease known, forming complex homooligomers of molecular weights up to 6MDa Homo sapiens

Synonyms

Synonyms Comment Organism
meprin alpha
-
 Homo sapiens

General Information

General Information Comment Organism
evolution meprin alpha belongs to the astacin family of zinc-endopeptidases and the metzincin superfamily, characterized by the conserved motif HExxHxxGxxHxxxRxDR Homo sapiens
physiological function meprins cleave compounds of the extracellular matrix such as laminin-V, collagen IV, fibronectin or nidogen 1, but also growth factors, cytokines and peptide hormones, including bradykinin, angiotensins, and gastrin Homo sapiens