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Literature summary for 3.4.24.80 extracted from
- Heterotrimeric G proteins directly regulate MMP14/membrane type-1 matrix metalloprotease. A novel mechanism for GPCR-EGFR transactivation (2015), J. Biol. Chem., 290, 9941-9947 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| angiotensin II | - |
Rattus norvegicus |  |
| angiotensin II | - |
Mus musculus | |
| G protein | MMP14 is directly activated by G protein betagamma subunits in a membrane-delimited manner, mechanism, overview | Mus musculus | |
| G protein | MMP14 is directly activated by G protein betagamma subunits in a membrane-delimited manner, mechanism, overview. Gallein inhibits stimulation of MMP14 activity by GTPgammaS in cardiac myocyte membranes | Rattus norvegicus | |
| GTP | - |
Rattus norvegicus | |
| GTP | - |
Mus musculus | |
| guanosine 5'-O-[gamma-thio]triphosphate | GTPgammaS | Rattus norvegicus | |
| guanosine 5'-O-[gamma-thio]triphosphate | GTPgammaS | Mus musculus | |
| additional information | MT1-MMP activation does not occur in response to GMP or adenosine 5'-[gamma-thio]triphosphate (ATPgammaS). The activation is specific to MMP14 as it is inhibited by a specific MMP14 peptide inhibitor and siRNA knockdown. MMP14 activation by GTPgammaS is pertussis toxin-sensitive | Rattus norvegicus | |
| additional information | MT1-MMP activation does not occur in response to GMP or adenosine 5'-[gamma-thio]triphosphate (ATPgammaS). The activation is specific to MMP14 as it is inhibited by a specific MMP14 peptide inhibitor and siRNA knockdown. MMP14 activation by GTPgammaS is pertussis toxin-sensitive | Mus musculus | |
| phenylephrine | - |
Rattus norvegicus | |
| phenylephrine | - |
Mus musculus | |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | siRNA-mediated knockout of MMP14 in NIH3T3 cells | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Rattus norvegicus | 5886 | - |
| plasma membrane | - |
Mus musculus | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | a zinc-dependent endopeptidase | Rattus norvegicus | |
| Zn2+ | a zinc-dependent endopeptidase | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P53690 | - |
- |
| Rattus norvegicus | Q10739 | - |
- |
| Rattus norvegicus Sprague-Dawley | Q10739 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | guanosine 5'-O-[gamma-thio]triphosphate (GTPgammaS)-stimulated activation of MMP14 | Rattus norvegicus |
| proteolytic modification | guanosine 5'-O-[gamma-thio]triphosphate (GTPgammaS)-stimulated activation of MMP14 | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cardiofibroblast | - |
Rattus norvegicus | - |
| cardiomyocyte | - |
Rattus norvegicus | - |
| NIH-3T3 cell | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| membrane type-1 matrix metalloprotease | - |
Rattus norvegicus |
| membrane type-1 matrix metalloprotease | - |
Mus musculus |
| MMP14 | - |
Rattus norvegicus |
| MMP14 | - |
Mus musculus |
| MT1-MMP | - |
Rattus norvegicus |
| MT1-MMP | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
| 37 | - |
assay at | Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | heterotrimeric G proteins directly regulate membrane-localized MMP14/MT1-MMP, resulting in HB-EGF release and EGF receptor transactivation. Analysis of the membrane-delimited mechanism for EGF receptor transactivation. MMP14 is a heterotrimeric G protein-regulated effector | Rattus norvegicus |
| physiological function | heterotrimeric G proteins directly regulate membrane-localized MMP14/MT1-MMP, resulting in HB-EGF release and EGF receptor transactivation. Analysis of the membrane-delimited mechanism for EGFreceptor transactivation. MMP14 is a heterotrimeric G protein-regulated effector | Mus musculus |
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