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Literature summary for 3.4.25.2 extracted from

  • Kebe, N.M.; Samanta, K.; Singh, P.; Lai-Kee-Him, J.; Apicella, V.; Payrot, N.; Lauraire, N.; Legrand, B.; Lisowski, V.; Mbang-Benet, D.E.; Pages, M.; Bastien, P.; Kajava, A.V.; Bron, P.; Hernandez, J.F.; Coux, O.
    The HslV protease from Leishmania major and its activation by C-terminal HslU peptides (2019), Int. J. Mol. Sci., 20, 1021 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.25.2

Activating Compound

Activating Compound Comment Organism Structure
additional information protease HslV can be activated by peptides derived from the C-termini of both ATPase isoforms HslU1 and HslU2. Five out of the six C-terminal residues of HslU2 are essential for binding to and activating HslV. Dodecapeptides derived from HslU of other parasites and bacteria are able to activate HslV with similar or even higher efficiency Leishmania major

Organism

Organism UniProt Comment Textmining
Leishmania major A4HWA6 subunit HslU1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-EVNL-7-amido-4-methylcoumarin + H2O
-
 Leishmania major benzyloxycarbonyl-EVNL + 7-amino-4-methylcoumarin
-
 ?
benzyloxycarbonyl-GGL-7-amido-4-methylcoumarin + H2O
-
 Leishmania major benzyloxycarbonyl-GGL + 7-amino-4-methylcoumarin
-
 ?
succinyl-LLVY-7-amido-4-methylcoumarin + H2O
-
 Leishmania major succinyl-LLVY + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
LINF_150005800 gene name, isoform HslU1 Leishmania major

General Information

General Information Comment Organism
physiological function protease HslV can be activated by peptides derived from the C-termini of both ATPase isoforms HslU1 and HslU2. Five out of the six C-terminal residues of HslU2 are essential for binding to and activating HslV. Dodecapeptides derived from HslU of other parasites and bacteria are able to activate HslV with similar or even higher efficiency Leishmania major